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dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorBahadır Acıkara, Özlem
dc.contributor.authorÖz, Burçin Ergene
dc.contributor.authorÖzbilgin, Serkan
dc.contributor.authorKırmızı, Neriman İpek
dc.contributor.authorÖzrenk, Bade Cevriye
dc.contributor.authorTekin, Mehmet
dc.contributor.authorSaltan, Gülçin
dc.date.accessioned2019-12-27T06:01:52Z
dc.date.available2019-12-27T06:01:52Z
dc.date.issued2019en_US
dc.identifier.citationÖzbek, H., Bahadır Acıkara, Ö., Öz, B. E., Özbilgin, S., Kırmızı, N. İ., Özrenk, B. C. ... Saltan, G. (2019). Antidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic mice. Brazilian Journal of Pharmaceutical Sciences, 55. https://dx.doi.org/10.1590/s2175-97902019000118157en_US
dc.identifier.issn1984-8250
dc.identifier.urihttps://doi.org/10.1590/s2175-97902019000118157
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4747
dc.description.abstractIn the current study, four Onobrychis species, O. albiflora Hub.-Mor., O. argyrea Boiss. subsp. argyrea Boiss., O. galegifolia Boiss., and O. tournefortii (Willd.) Desv. were collected from Anatolia to be evaluated for their antidiabetic activities. Methanol water extracts of the aerial parts were used for experiments. An alloxan-induced diabetic mice test model was used. Phytochemical analysis of the tested extracts was investigated using the HPLC method. The highest activity was observed with treatment of O. albiflora aerial part extract. Significant decrements were detected in the blood glucose levels as follows: 180.83±47.48 and 252.83±50.47mg/dL at 100 mg/kg and 200 mg/kg doses of O. albiflora, respectively, when compared to the isotonic saline solution control group, eliciting a blood glucose level of 494.20±27.32. Among the tested standard compounds, rutin and isoquercetin were detected in the examined species. The highest amount of rutin (1.1981±0.0017%) and isoquercetin (0.7318±0.0197%) were found in O. albiflora and O. argyrea subsp. argyrea, respectively. Antidiabetic activities of the tested Onobrychis species seem to indicate a possible correlation with their rutin and isoquercetin contents. Therefore, rutin and isoquercetin may be the antidiabetic compounds that contribute to the antidiabetic activity of the tested Onobrychis species.en_US
dc.language.isoengen_US
dc.publisherFaculdade de Ciencias Farmaceuticas (Biblioteca)en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectOnobrychisen_US
dc.subjectAntidiabetic Activityen_US
dc.subjectAlloxanen_US
dc.subjectRutinen_US
dc.subjectIsoquercetinen_US
dc.subjectPhytochemical Analysisen_US
dc.titleAntidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic miceen_US
dc.typearticleen_US
dc.relation.journalBrazilian Journal of Pharmaceutical Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Farmakoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, İş Sağlığı ve Güvenliği Ana Bilim Dalıen_US
dc.authorid0000-0002-8084-7855en_US
dc.identifier.volume55en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1590/s2175-97902019000118157en_US


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