Show simple item record

dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorBahadır Acıkara, Özlem
dc.contributor.authorÖz, Burçin Ergene
dc.contributor.authorÖzbilgin, Serkan
dc.contributor.authorKırmızı, Neriman İpek
dc.contributor.authorÖzrenk, Bade Cevriye
dc.contributor.authorTekin, Mehmet
dc.contributor.authorSaltan, Gülçin
dc.identifier.citationÖzbek, H., Bahadır Acıkara, Ö., Öz, B. E., Özbilgin, S., Kırmızı, N. İ., Özrenk, B. C. ... Saltan, G. (2019). Antidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic mice. Brazilian Journal of Pharmaceutical Sciences, 55.
dc.description.abstractIn the current study, four Onobrychis species, O. albiflora Hub.-Mor., O. argyrea Boiss. subsp. argyrea Boiss., O. galegifolia Boiss., and O. tournefortii (Willd.) Desv. were collected from Anatolia to be evaluated for their antidiabetic activities. Methanol water extracts of the aerial parts were used for experiments. An alloxan-induced diabetic mice test model was used. Phytochemical analysis of the tested extracts was investigated using the HPLC method. The highest activity was observed with treatment of O. albiflora aerial part extract. Significant decrements were detected in the blood glucose levels as follows: 180.83±47.48 and 252.83±50.47mg/dL at 100 mg/kg and 200 mg/kg doses of O. albiflora, respectively, when compared to the isotonic saline solution control group, eliciting a blood glucose level of 494.20±27.32. Among the tested standard compounds, rutin and isoquercetin were detected in the examined species. The highest amount of rutin (1.1981±0.0017%) and isoquercetin (0.7318±0.0197%) were found in O. albiflora and O. argyrea subsp. argyrea, respectively. Antidiabetic activities of the tested Onobrychis species seem to indicate a possible correlation with their rutin and isoquercetin contents. Therefore, rutin and isoquercetin may be the antidiabetic compounds that contribute to the antidiabetic activity of the tested Onobrychis species.en_US
dc.publisherFaculdade de Ciencias Farmaceuticas (Biblioteca)en_US
dc.rightsAttribution 4.0 International*
dc.subjectAntidiabetic Activityen_US
dc.subjectPhytochemical Analysisen_US
dc.titleAntidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic miceen_US
dc.relation.journalBrazilian Journal of Pharmaceutical Sciencesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Farmakoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, İş Sağlığı ve Güvenliği Ana Bilim Dalıen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

Except where otherwise noted, this item's license is described as info:eu-repo/semantics/openAccess