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dc.contributor.authorErdem, Semiha Bahçeci
dc.contributor.authorGülez, Nesrin
dc.contributor.authorGenel, Ferah
dc.contributor.authorKaraman, Sait
dc.contributor.authorNacaroǧlu, Hikmet Tekin
dc.date.accessioned2019-12-26T11:22:59Z
dc.date.available2019-12-26T11:22:59Z
dc.date.issued2019en_US
dc.identifier.citationErdem, S. B., Gülez, N., Genel, F., Karaman, S. ve Nacaroǧlu, H. T. (2019). Characteristics of the patients followed with the diagnosis of common variable immunodeficiency and the complications. Central European Journal of Immunology, 44(2), 119-126. https://doi.org/10.5114/ceji.2019.87060en_US
dc.identifier.issn1426-3912
dc.identifier.urihttps://doi.org/10.5114/ceji.2019.87060
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4732
dc.description.abstractIntroduction: In this study, we aimed to retrospectively evaluate the clinical and laboratory findings and complications of 28 common variable immunodeficiency (CVID) patients. Material and methods: The clinical features and laboratory data of 28 CVID patients were evaluated. Results: Nineteen patients were male. In 53.5% of the cases, complications included inflammatory bowel disease, cytopenia, bronchiectasis, granulomatous lymphocytic interstitial lung disease (ILD) and asthma. In their immunological evaluations, IgG, IgM, and IgA mean values were 474.8 ±214.1 mg/dl; 56.7 ±41.9 mg/dl; 35.3 ±58.2 mg/dl, respectively, and the vaccine response was positive in 64.2% of the cases. In all age groups, absolute lymphocyte counts, naive (CD19+IgD+27-), nonswitch (CD19+IgD-27+) memory B cells were numerically higher when compared to the data of healthy children; however, although switch memory (CD19+IgD+27+) B cells were proportionally low in the 4-8 and 12-18 age groups, they were low both numerically and proportionally in the 8-12 age group. No statistically significant difference was found between the cases with complications and without complications. But the cases with pulmonary complications were compared within the group, the CD8 ratio was high but the IgA level was low in patients with bronchiectasis and CD3 was numerically and proportionally low in the cases with ILD compared to others. According to the Paris classification, 11/27 (40.7%) of the cases, 3/27 (11.1%) of them and 13/27 (48.2%) of them were evaluated as MB0, MB1, and MB2, respectively. Conclusions: In genetic studies, TACI (trans-membrane activator and calcium-modulating cyclophilin ligand interactor – TNFRSF13B) mutation was found positive in 25% of the cases.en_US
dc.language.isoengen_US
dc.publisherTermedia Publishing House Ltd.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPrimary Immunodeficiencyen_US
dc.subjectHypogammaglobulinemiaen_US
dc.subjectCommon Variable Immunodeficiencyen_US
dc.subjectTACIen_US
dc.titleCharacteristics of the patients followed with the diagnosis of common variable immunodeficiency and the complicationsen_US
dc.typearticleen_US
dc.relation.journalCentral European Journal of Immunologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0003-1333-2648en_US
dc.identifier.volume44en_US
dc.identifier.issue2en_US
dc.identifier.startpage119en_US
dc.identifier.endpage126en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5114/ceji.2019.87060en_US


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