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dc.contributor.authorGüzeldemir Akçakanat, Esra
dc.contributor.authorAlkan, Begüm
dc.contributor.authorSünnetçi Akkoyunlu, Deniz
dc.contributor.authorGürel, Büşra
dc.contributor.authorBalta, Vecihe Merve
dc.contributor.authorKan, Bahadır
dc.contributor.authorAkgün, Emel
dc.contributor.authorYılmaz, Elif Büşra
dc.contributor.authorTarık Baykal, Ahmet
dc.contributor.authorCine, Naci
dc.contributor.authorOlgaç, Vakur
dc.contributor.authorGümüşlü, Esen
dc.contributor.authorSavlı, Hakan
dc.date.accessioned2019-12-24T12:50:03Z
dc.date.available2019-12-24T12:50:03Z
dc.date.issued2019en_US
dc.identifier.citationGüzeldemir Akçakanat, E., Alkan, B., Sünnetçi Akkoyunlu, D., Gürel, B., Balta, V. M., Kan, B. ... Savlı, H. (2019). Molecular signatures of chronic periodontitis in gingiva: A genomic and proteomic analysis. Journal of Periodontology, 90(6), 663-673. http://doi.org/10.1002/JPER.18-0477en_US
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.urihttp://doi.org/10.1002/JPER.18-0477
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4652
dc.description.abstractBackground: To elucidate molecular signatures of chronic periodontitis (CP) using gingival tissue samples through omics-based whole-genome transcriptomic and whole protein profiling. Methods: Gingival tissues from 18 CP and 25 controls were analyzed using gene expression microarrays to identify gene expression patterns and the proteins isolated from these samples were subjected to comparative proteomic analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The data from transcriptomics and proteomics were integrated to reveal common shared genes and proteins. Results: The most upregulated genes in CP compared with controls were found as MZB1, BMS1P20, IGLL1/IGLL5, TNFRSF17, ALDH1A1, KIAA0125, MMP7, PRL, MGC16025, ADAM11, and the most upregulated proteins in CP compared with controls were BPI, ITGAM, CAP37, PCM1, MMP-9, MZB1, UGTT1, PLG, RAB1B, HSP90B1. Functions of the identified genes were involved cell death/survival, DNA replication, recombination/repair, gene expression, organismal development, cell-to-cell signaling/interaction, cellular development, cellular growth/proliferation, cellular assembly/organization, cellular function/maintenance, cellular movement, B-cell development, and identified proteins were involved in protein folding, response to stress, single-organism catabolic process, regulation of peptidase activity, and negative regulation of cell death. The integration and validation analysis of the transcriptomics and proteomics data revealed two common shared genes and proteins, MZB1 and ECH1. Conclusion: Integrative data from transcriptomics and proteomics revealed MZB1 as a potent candidate for chronic periodontitis.en_US
dc.description.sponsorshipKocaeli Universityen_US
dc.language.isoengen_US
dc.publisherWiley-Blackwellen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectChronic Periodontitisen_US
dc.subjectEnoyl-CoA Hydrataseen_US
dc.subjectInflammationen_US
dc.subjectGenomicsen_US
dc.subjectGingivaen_US
dc.subjectProteomicsen_US
dc.subjectProteogenomicsen_US
dc.subjectpERp1en_US
dc.titleMolecular signatures of chronic periodontitis in gingiva: A genomic and proteomic analysisen_US
dc.typearticleen_US
dc.relation.journalJournal of Periodontologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalıen_US
dc.identifier.volume90en_US
dc.identifier.issue6en_US
dc.identifier.startpage663en_US
dc.identifier.endpage673en_US
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/214S008en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/JPER.18-0477en_US


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