dc.contributor.author | Güler, Özlem | |
dc.contributor.author | Özer, Alev | |
dc.contributor.author | Seyithanoğlu, Muhammet | |
dc.contributor.author | Yaman, Fatih Nazmi | |
dc.contributor.author | Şahpaz Kurşun, Huri Nigar | |
dc.date.accessioned | 2019-12-23T12:51:38Z | |
dc.date.available | 2019-12-23T12:51:38Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Güler, Ö., Özer, A., Seyithanoğlu, M., Yaman, F. N. ve Şahpaz Kurşun, H.N. (2021). Serum amphiregulin and cerebellin-1 levels in severe preeclampsia. The Journal of Maternal-Fetal & Neonatal Medicine, 34(17), 2863-2868. https://doi.org/10.1080/14767058.2019.1671345 | en_US |
dc.identifier.uri | https://doi.org/10.1080/14767058.2019.1671345 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/4616 | |
dc.description.abstract | Purpose: Preeclampsia is a form of hypertensive disorders of pregnancy and defined as the presence of new-onset hypertension and proteinuria or other end organ damage occurring after 20-week gestation. Preeclampsia can be a destructive process that can cause maternal and infant mortality. The exact etiopathogenesis of preeclampsia is still undefined. We aimed to compare serum amphiregulin and cerebellin-1 levels of severe preeclampsia patients with healthy pregnant women and healthy control subjects. Materials and methods: A total of 88 women were enrolled in this study. Patients diagnosed with severe preeclampsia were group 1 (n?=?28), healthy non-pregnant normotensive women group 2 (n?=?30), and healthy pregnant women group 3 (n?=?30). The participants in each group were matched for age. Pregnant women in groups 1 and 3 were also matched for gestational age. Serum amphiregulin and cerebellin-1 levels were measured using ELISA. Results: Serum amphiregulin levels were 3413???1.38?ng/ml (1748?7739), 8510???7213?ng/ml (2019?24,000), and 6580???5360?ng/ml (2484?24,000) in preeclampsia patients, controls and healthy pregnant women, respectively. Amphiregulin levels were significantly lower in preeclampsia patients than healthy pregnant women (p=.008) and controls (p?=?.015). Amphiregulin levels were similar between healthy controls and healthy pregnant women (p??=??1.00). Cerebellin-1 levels were 222.039???92.681?pg/ml (138,580?557,757) in preeclamptic patients, 537.043???525.117?pg/ml (150,432?1,600,000) in controls and 415.091???436.580?pg/ml (137,284?1,600,000) in healthy pregnant women. Cerebellin-1 levels were similar among groups (p?=?.272). Serum amphiregulin and cerebellin-1 levels were significantly and positively correlated with each other in preeclampsia patients (r??=??0.693, p?<?.001), controls (r??=??0.882, p?<?.001), and healthy pregnant women (r??=??0.591, p?=?.001). Serum level of amphiregulin ?3590?pg/ml had a sensitivity of 67.9% and specificity of 63.3% in the diagnosis of preeclampsia (AUC: 0.751; p?=?.001). Conclusions: Serum amphiregulin decreases in severe preeclampsia patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Amphiregulin | en_US |
dc.subject | Cerebellin | en_US |
dc.subject | Preeclampsia | en_US |
dc.subject | Pregnancy | en_US |
dc.title | Serum amphiregulin and cerebellin-1 levels in severe preeclampsia | en_US |
dc.type | article | en_US |
dc.relation.ispartof | The Journal of Maternal-Fetal & Neonatal Medicine | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-1555-4658 | en_US |
dc.identifier.volume | 34 | en_US |
dc.identifier.issue | 17 | en_US |
dc.identifier.startpage | 2863 | en_US |
dc.identifier.endpage | 2868 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1080/14767058.2019.1671345 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q2 | en_US |