dc.contributor.author | Terzi, Cem | |
dc.contributor.author | Bingül, Meryem | |
dc.contributor.author | Arslan, Naciye Çiǧdem | |
dc.contributor.author | Öztürk, Ersin | |
dc.contributor.author | Canda, Aras Emre | |
dc.contributor.author | Işık, Özgen | |
dc.contributor.author | Yılmazlar, Tuncay | |
dc.contributor.author | Obuz, Funda | |
dc.contributor.author | Görken, İlknur Bilkay | |
dc.contributor.author | Kurt, Meral A. | |
dc.contributor.author | Ünlü, Mehtat Ş. | |
dc.contributor.author | Uǧraş, Nesrin | |
dc.contributor.author | Kanat, Özkan | |
dc.contributor.author | Öztop, İlhan | |
dc.date.accessioned | 2019-12-23T12:41:18Z | |
dc.date.available | 2019-12-23T12:41:18Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Terzi, C., Bingül, M., Arslan, N. Ç., Öztürk, E., Canda, A. E., Işık, Ö. ... Öztop, İ. (2020). Randomized controlled trial of 8 weeks' vs 12 weeks' interval between neoadjuvant chemoradiotherapy and surgery for locally advanced rectal cancer. Colorectal Disease, 22(3), 279-288. https://doi.org/10.1111/codi.14867 | en_US |
dc.identifier.uri | https://doi.org/10.1111/codi.14867 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/4614 | |
dc.description.abstract | Aim The aim was to compare the pathological complete response (pCR) rate at 8 compared to 12 weeks' interval between completion of neoadjuvant chemoradiotherapy (CRT) and surgery in patients with locally advanced rectal cancer. Method This was a randomized trial which included a total of 330 patients from two institutions. Patients with locally advanced (T3-4N0M0, TxN+M0) rectal cancer were randomized into 8- and 12-week interval groups. All the patients received long-course CRT (45 Gy in 1.8 Gy fractions and concomitant oral capecitabine or 5-fluorouracil infusion). Surgery was performed at either 8 or 12 weeks after CRT. The primary end-point was pCR. Secondary end-points were sphincter preservation, postoperative morbidity and mortality. Results Two-hundred and fifty-two patients (n = 125 in the 8-week group, n = 127 in the 12-week group) were included. Demographic and clinical characteristics were similar between groups. The overall pCR rate was 17.9% (n = 45): 12% (n = 15) in the 8-week group and 23.6% (n = 30) in the 12-week group (P = 0.021). Sphincter-preserving surgery was performed in 107 (85.6%) patients which was significantly higher than the 94 (74%) patients in the 12-week group (P = 0.016). Postoperative mortality was seen in three (1.2%) patients overall and was not different between groups (1.6% in 8 weeks vs 0.8% in 12 weeks, P = 0.494). Groups were similar in anastomotic leak (10.8% in 8 weeks vs 4.5% in 12 weeks, P = 0.088) and morbidity (30.4% in 8 weeks and 20.1% in 12 weeks, P = 0.083). Conclusion Extending the interval between CRT and surgery from 8 to 12 weeks resulted in a 2-fold increase in pCR rate without any difference in mortality and morbidity. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Rectal Cancer | en_US |
dc.subject | Neoadjuvant Chemoradiotherapy | en_US |
dc.subject | Interval | en_US |
dc.subject | Complete Response | en_US |
dc.title | Randomized controlled trial of 8 weeks' vs 12 weeks' interval between neoadjuvant chemoradiotherapy and surgery for locally advanced rectal cancer | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Colorectal Disease | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-2282-7207 | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 279 | en_US |
dc.identifier.endpage | 288 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1111/codi.14867 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q2 | en_US |