dc.contributor.author | Çalıbaşı-Kocal, Gizem | |
dc.contributor.author | Pakdemirli, Ahu | |
dc.contributor.author | Bayrak, Serdar | |
dc.contributor.author | Özüpek, Nazlı Mert | |
dc.contributor.author | Sever, Tolga | |
dc.contributor.author | Başbınar, Yasemin | |
dc.contributor.author | Ellidokuz, Hülya | |
dc.contributor.author | Yiğitbaşı, Türkan | |
dc.date.accessioned | 2019-12-20T13:14:42Z | |
dc.date.available | 2019-12-20T13:14:42Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Çalıbaşı-Kocal, G., Pakdemirli, A., Bayrak, S., Özüpek, N. M., Sever, T., Başbınar, Y. ... Yiğitbaşı, T. (2019). Curcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer. Journal of B.U.ON, 24(4), 1482-1487. | en_US |
dc.identifier.issn | 11070625 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/4584 | |
dc.description.abstract | Purpose: Curcumin is a natural phytopolyphenol compound isolated from the root of turmeric (Curcuma longa) and possesses a wide range of biological properties. The purpose of this study was to evaluate the antiproliferative, wound healing, anti-invasive and anti-migrative effects of curcumin on HCT-116 and LoVo colorectal cancer cell lines. Methods: The antiproliferative activity of 2.5-75 µM curcumin was tested on HCT-116 and LoVo colorectal cell lines and the viability of the cells was tested with WST-1 reagent by using ELISA plate reader at 450 nm. xCELLigence RTCA DP system was used for the detection of anti-invasive and anti-migrative effects of curcumin. Results: The IC50 of curcumin was 10±0.03 for HCT-116 and 20±0.05 µM for LoVo cell lines. The IC50 of curcumin (10µM for HCT-116 and 20 µM for LoVo) showed anti-metastatic activity on these cell lines. Conclusion: This study showed that curcumin could be evaluated as a promising anti-cancer agent for human colorectal cancer. | en_US |
dc.description.sponsorship | Dokuz Eylul University | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Zerbinis Publications | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Colorectal Cancer | en_US |
dc.subject | Curcumin | en_US |
dc.subject | Invasion | en_US |
dc.subject | Migration | en_US |
dc.subject | Proliferation | en_US |
dc.title | Curcumin effects on cell proliferation, angiogenesis and metastasis in colorectal cancer | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of B.U.ON | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0675-1839 | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 1482 | en_US |
dc.identifier.endpage | 1487 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.wosquality | Q4 | en_US |