dc.contributor.author | Koyuncu Sökmen, Bedriye | |
dc.contributor.author | Sabet, Soheil | |
dc.contributor.author | Öz, Ayşegül | |
dc.contributor.author | Server, Sadık | |
dc.contributor.author | Namal, Esat | |
dc.contributor.author | Dayangaç, Murat | |
dc.contributor.author | Bülbül Doǧusoy, Gülen | |
dc.contributor.author | Tokat, Yaman | |
dc.contributor.author | İnan, Nagihan | |
dc.date.accessioned | 2019-12-20T12:42:55Z | |
dc.date.available | 2019-12-20T12:42:55Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Koyuncu Sökmen, B., Sabet, S., Öz, A., Server, S., Namal, E., Dayangaç, M. ... İnan, N. (2019). Value of intravoxel incoherent motion for hepatocellular carcinoma grading. Transplantation Proceedings, 51(6), 1861-1866. http://dx.doi.org/10.1016/j.transproceed.2019.02.027 | en_US |
dc.identifier.issn | 0041-1345 | |
dc.identifier.issn | 1873-2623 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.transproceed.2019.02.027 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/4582 | |
dc.description.abstract | Background: To evaluate the diagnostic accuracy of intravoxel incoherent motion (IVIM) parameters in estimation of hepatocellular carcinoma (HCC) grading. Materials and methods: Twenty-nine patients with histopathologically diagnosed as 42 HCC at explant were included in this retrospective study. All patients were examined by 1.5T magnetic resonance imaging with the use of 4-channel phased array body coil. In addition to routine pre- and postcontrast sequences, IVIM (16 different b factors varying from 0 to 1300 s/mm2) and conventional diffusion-weighted imaging (3 different b factors of 50, 400, 800 s/mm2) were obtained with single-shot echo planar spin echo sequence. Apparent diffusion coefficient (ADC) and IVIM parameters including mean D (true diffusion coefficient), D* (pseudo-diffusion coefficient associated with blood flow), and f (perfusion fraction) values were calculated. Histopathologically, HCC was classified as low (grade 1, 2) and high (grade 3, 4) grade in accordance with the Edmondson-Steiner score. Quantitatively, ADC, D, D*, and f values were compared between the low- and high-grade groups by Student t test. The relationship between the parameters and histologic grade was analyzed using the Spearman's correlation test. To evaluate the diagnostic performance of the parameters, receiver operating characteristic analysis was performed. Results: High-grade HCCs had significantly lower ADC and D values than low grade groups (P = .005 and P = .026, retrospectively); ADC and D values were inversely correlated with tumor grade (r = –0.519, P = .011, r = –0.510, P = .026, respectively). High-grade HCCs had significantly higher f values when compared with the low-grade group (P = .005). The f values were positively correlated with tumor grade (r = 0.548, P = .007). The best discriminative parameter was f value. Cut-off value of 32% of f values showed sensitivity of 75.6% and a specificity of 73.5%. Conclusion: ADC values and IVIM parameters such as f values appear to reflect the grade of HCCs. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier USA | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Apparent Diffusion-Coefficient | en_US |
dc.subject | Monoexponential Model | en_US |
dc.subject | Histological Grade | en_US |
dc.subject | Mri | en_US |
dc.subject | Differentiation | en_US |
dc.subject | Diagnosis | en_US |
dc.title | Value of intravoxel incoherent motion for hepatocellular carcinoma grading | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Transplantation Proceedings | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-1240-7233 | en_US |
dc.identifier.volume | 51 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 1861 | en_US |
dc.identifier.endpage | 1866 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.transproceed.2019.02.027 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |