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dc.contributor.authorHanoğlu, Taha
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorAktürk, Tuba
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2019-12-19T13:10:04Z
dc.date.available2019-12-19T13:10:04Z
dc.date.issued2019en_US
dc.identifier.citationHanoğlu, T., Hanoğlu, L., Güntekin, B., Aktürk, T. ve Yuluğ, B. (2019). The therapeutic role of repetitive transcranial magnetic stimulation (rTMS) in parkinsonian visual hallucinations: Electrophysiological correlates. Journal of Clinical Neuroscience, 69, 281-284. https://doi.org/10.1016/j.jocn.2019.08.002en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2019.08.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4558
dc.description.abstractWe have evaluated an 82 years old PD patient who has acutely developed VH secondary to acute visual loss that was associated with increased electroencephalographic activity in the gamma range over the parietal, occipital and frontal regions. In this respect, we have tested the therapeutic effect of occipital lobe oriented rTMS application and its electrophysiological correlates that led to significant improvement in the hallucinatory symptomatology of the patient after two weeks. We have revealed that the improved hallucinatory symptoms after rTMS application resolved completely after switching from the pramipexole treatment to L-Dopa indicating that there could be a combined therapeutic effect of L-Dopa and rTMS. Furthermore, Quantitative-Electroencephalography analysis has shown that the therapeutic effects of rTMS and L-Dopa were seen with the improvement of impaired gamma power spectrum. Although the main limitation of this report is that this a single case study and that these findings need to be replicated in a larger sample, e.g., as part of a controlled trial, our present findings help us to enlighten the unknown pathophysiological overlapping between the visual hallucinations in PD and Charles Bonnet Syndrome. Finally, our study revealed increased gamma coherence and power spectrum which is seen with visual hallucinations and improved after the application of 1 Hz rTMS on the occipital lobe. These findings together suggest that rTMS could be used as a therapeutic tool for parkinsonian complex VH and probably due affecting gamma coherence and power spectrum.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Ltden_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectrTMSen_US
dc.subjectVisual Hallucinationen_US
dc.subjectParkinson’s Diseaseen_US
dc.subjectCharles Bonnet Syndromeen_US
dc.subjectQ-EEGen_US
dc.subjectCoherenceen_US
dc.subjectPower Spectrumen_US
dc.subjectGamma Activityen_US
dc.titleThe therapeutic role of repetitive transcranial magnetic stimulation (rTMS) in parkinsonian visual hallucinations: Electrophysiological correlatesen_US
dc.typearticleen_US
dc.relation.journalJournal of Clinical Neuroscienceen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-4292-5717en_US
dc.authorid0000-0002-0860-0524en_US
dc.authorid0000-0002-7555-3801en_US
dc.identifier.volume69en_US
dc.identifier.startpage281en_US
dc.identifier.endpage284en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jocn.2019.08.002en_US


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