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dc.contributor.authorKaplan, Necati
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKaraaslan, Numan
dc.contributor.authorYaşar Şirin, Duygu
dc.contributor.authorŞimşek, Abdullah Talha
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorBircan, Rıfat
dc.contributor.authorÖzbek, Hanefi
dc.date.accessioned2019-12-19T06:10:18Z
dc.date.available2019-12-19T06:10:18Z
dc.date.issued2019en_US
dc.identifier.citationKaplan, N., Yılmaz, İ., Karaaslan, N., Yaşar Şirin, D., Şimşek, A. T., Çalışkan, T. ... Özbek, H. (2019). Evaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissue. Turkish Neurosurgical, 29(4), 522-529. https://doi.org/10.5137/1019-5149.JTN.24447-18.3en_US
dc.identifier.issn1019-5149
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.24447-18.3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4528
dc.description.abstractAIM: To evaluate the effects of pre- and intra-operatively administered daptomycin (DAP) on the intact human primary intervertebral disc tissue cells. MATERIAL and METHODS: Primary cell cultures were established using tissues obtained through decompressive laminectomy, traumatic intervertebral disc herniation excision, and posterior transpedicular stabilization. Non-drug-administered samples were used as a control group. The samples treated with DAP formed the study group. Molecular assays for proliferation and gene expression were performed. The obtained data were evaluated statistically, and results with a value of p<0.05 were accepted as significant. RESULTS: While no reduction was observed in the proliferation, the gene expression of intact intervertebral disc tissue cells was time-dependently decreased compared to the control group, and these results were reported to be statistically significant. CONCLUSION: This study observed the effect that a pharmaceutical preparation, which was used on intervertebral disc tissue before and after the operation, had on normal, healthy, and intact tissue. It concludes that alterations in the expression of genes involved in the anabolic and/or catabolic process, even in adjacent healthy tissue, may slow down the healing process of the damaged tissue or cause undesired cell differentiation.en_US
dc.language.isoengen_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntervertebral Discen_US
dc.subjectCHADen_US
dc.subjectCOMPen_US
dc.subjectDaptomycinen_US
dc.subjectIL-1βen_US
dc.subjectMMPsen_US
dc.titleEvaluation of the effect of daptomycin, a glycopeptide agent, on intact intervertebral disc tissueen_US
dc.typearticleen_US
dc.relation.ispartofTurkish Neurosurgicalen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-2003-6337en_US
dc.authorid0000-0002-8084-7855en_US
dc.identifier.volume29en_US
dc.identifier.issue4en_US
dc.identifier.startpage522en_US
dc.identifier.endpage529en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5137/1019-5149.JTN.24447-18.3en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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