Yazar "Demircan, Turan" için Makale Koleksiyonu listeleme
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Aksolotl rejenerasyonunun farklı evrelerinde miRNA profilinin bulunması ve bulunan miRNA'ların görevlerinin in-siliko analizi
Giriş ve Amaç: Rejenerasyon, fonksiyonel bir kayıp yaşamadan hasarlı dokunun, organın ya da uzvun restore edilmesi işlemidir. Su semenderlerinden olan Aksolotl kendisini öldürmeyecek iç organ, merkezi sinir sistemi ve uzuv ... -
Axolotl cells and tissues enhances cutaneous wound healing in mice
Demircan, Turan; Keskin, İlknur; Günal, Yalçın; İlhan, Ayşe Elif; Kolbaşı, Bircan; Öztürk, Gürkan (2016)Adult mammalian skin wound repair is defective due to loss of the regulation in balancing the complete epithelial regeneration and excessive connective tissue production, and this repair process commonly results in scar ... -
A comparative study of fixatives for axolotl blastema tissue
Keskin, İlknur; Yıldırım, Berna; Kolbaşı, Bircan; Öztürk, Gürkan; Demircan, Turan (Soc Chilena Anatomia, 2017)Regeneration is defined as tissue renewal and functional restoration process of the damaged parts of the body after an injury. Ambystoma mexicanum, commonly named the Axolotl, is one of the unique vertebrates, which has a ... -
Comparison of protein expression profile of limb regeneration between neotenic and metamorphic axolotl
Sibai, Mustafa; Altuntaş, Ebru; Süzek, Barış Ethem; Şahin, Betül; Parlayan, Cüneyd; Öztürk, Gürkan; Baykal, Ahmet Tarık; Demircan, Turan (Elsevier, 2020)The axolotl (Ambystoma mexicanum) salamander, a urodele amphibian, has an exceptional regenerative capacity to fully restore an amputated limb throughout the life-long lasting neoteny. By contrast, when axolotls are ... -
Detailed tail proteomic analysis of axolotl (Ambystoma mexicanum) using an mRNA-seq reference database
Demircan, Turan; Keskin, İlknur; Dumlu, Seda Nilgün; Aytürk, Nilüfer; Avşaroğlu, Mahmut Erhan; Akgün, Emel; Öztürk, Gürkan; Baykal, Ahmet Tarık (Wiley, 2017)Salamander axolotl has been emerging as an important model for stem cell research due to its powerful regenerative capacity. Several advantages, such as the high capability of advanced tissue, organ, and appendages ... -
Downregulation of Yap1 during limb regeneration results in defective bone formation in axolotl
Bay, Sadık; Öztürk, Gürkan; Emekli, Nesrin; Demircan, Turan (Elsevier Inc., 2023)The Hippo pathway plays an imperative role in cellular processes such as differentiation, regeneration, cell migration, organ growth, apoptosis, and cell cycle. Transcription coregulator component of Hippo pathway, YAP1, ... -
Experimentally induced metamorphosis in highly regenerative axolotl (ambystoma mexicanum) under constant diet restructures microbiota
Demircan, Turan; Ovezmyradov, Guvanch; Yıldırım, Berna; Keskin, İlknur; İlhan, Ayşe Elif; Fesçioğlu, Ece Cana; Öztürk, Gürkan; Yıldırım, Süleyman (Nature Publishing Group, 2018)Axolotl (Ambystoma mexicanum) is a critically endangered salamander species and a model organism for regenerative and developmental biology. Despite life-long neoteny in nature and in captive-bred colonies, metamorphosis ... -
Fare östrus siklusu'nun farklı fazlarında plin2 ve plin3 ekspresyonu
Giriş: Puberteye kadar birinci mayozun profaz evresinde bekleyen primordiyal foliküllerden birkaçı puberte ile birlikte, hormonal uyarı altında her ay tekrarlayan bir serüvene başlar. Bu süreçte ovaryumun stromal hücreleri ... -
The first report on circulating microRNAs at Pre- and Post-metamorphic stages of axolotls
Demircan, Turan; Sibai, Mustafa; Avşaroğlu, Mahmut Erhan; Altuntaş, Ebru; Ovezmyradov, Guvanch (Elsevier, 2021)MicroRNAs (miRNAs) are endogenously coded small RNAs, implicated in post-transcriptional gene regulation by targeting messenger RNAs (mRNAs). Circulating miRNAs are cell-free molecules, found in body fluids, such as blood ... -
A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl
Demircan, Turan; İlhan, Ayşe Elif; Aytürk, Nilüfer; Yıldırım, Berna; Öztürk, Gürkan; Keskin, İlknur (Elsevier GmbH, 2016)Axolotl (Ambystoma Mexicanum) has been emerging as a promising model in stem cell and regeneration researches due to its exceptional regenerative capacity. Although it represents lifelong lasting neoteny, induction to ... -
Integrative analysis of axolotl gene expression data from regenerative and wound healing limb tissues
Sibai, Mustafa; Parlayan, Cüneyd; Tuğlu, Pelin; Öztürk, Gürkan; Demircan, Turan (Nature Research, 2019)Axolotl (Ambystoma mexicanum) is a urodele amphibian endowed with remarkable regenerative capacities manifested in scarless wound healing and restoration of amputated limbs, which makes it a powerful experimental model for ... -
Longitudinal 16S rRNA data derived from limb regenerative tissue samples of axolotl ambystoma mexicanum
Demircan, Turan; İlhan, Ayşe Elif; Ovezmyradov, Guvanch; Öztürk, Gürkan; Yıldırım, Süleyman (Nature Publishing Group, 2019)The Mexican axolotl (Ambystoma mexicanum) is a critically endangered species and a fruitful amphibian model for regenerative biology. Despite growing body of research on the cellular and molecular biology of axolotl limb ... -
Microbiome and longevity: High abundance of longevity-linked muribaculaceae in the gut of the long-living rodentspalax leucodon
Sibai, Mustafa; Altuntaş, Ebru; Yıldırım, Berna; Öztürk, Gürkan; Yıldırım, Süleyman; Demircan, Turan (Mary Ann Liebert Inc, 2020)With a world population living longer as well as marked disparities in life expectancy, understanding the determinants of longevity is one of the priority research agendas in 21st century life sciences. To this end, the ... -
Preclinical molecular signatures of spinal cord functional restoration: Optimizing the metamorphic axolotl (ambystoma mexicanum) model in regenerative medicine
Demircan, Turan; Hacıbektaşoğlu, Harbiye; Sibai, Mustafa; Cana Fesçioğlu, Ece; Altuntaş, Ebru; Öztürk, Gürkan; Süzek, Barış Ethem (Mary Ann Liebert, 2020)Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential ... -
Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
Demircan, Turan; Sibai, Mustafa; Altuntaş, Ebru (Elsevier, 2020)The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein ...