Bölüm "İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı" Makale Koleksiyonu için listeleme
Toplam kayıt 30, listelenen: 1-20
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ABCG5 and ABCG8 gene polymorphisms in type 2 diabetes mellitus in the Turkish population
(Elsevier, 2015)Objective: The aim of the present study was to investigate the relationship between ABCG5 and ABCG8 gene polymorphisms and plasma lipid concentrations in Turkish patients with type 2 diabetes mellitus. Methods: Included ... -
Active shrinkage protects neurons following axonal transection
(Elsevier Inc., 2023)Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water ... -
Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity
(Frontiers Media Sa, 2019)Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive treatment for stroke based on the data promoting its effects on functional recovery. However, the exact action mechanisms by which ... -
Antioxidant activity of blackthorn (Prunus spinosa L.) fruit extract and cytotoxic effects on various cancer cell lines
(Logos Medical Publishing, 2019)Objective: Blackthorn (Prunus spinosa L. (Rosaceae) is a shrup whose fruits are consumed as food in Turkey. This study was aimed to evaluate antioxidant activity of methanol extract of P. spinosa and its cytotoxic effects ... -
Axolotl cells and tissues enhances cutaneous wound healing in mice
(2016)Adult mammalian skin wound repair is defective due to loss of the regulation in balancing the complete epithelial regeneration and excessive connective tissue production, and this repair process commonly results in scar ... -
Cardiac immunology: A new era for immune cells in the heart
(Plenum Press, 2021)The immune system is essential for the development and homeostasis of the human body. Our current understanding of the immune system on disease pathogenesis has drastically expanded over the last decade with the definition ... -
Defining optimal enzyme and matrix combination for replating of human induced pluripotent stem cell-derived cardiomyocytes at different levels of maturity
(Elsevier Inc., 2021)Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) create an unlimited cell source for basic and translational research. Depending on the maturity of cardiac cultures and the intended applications, ... -
Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury
(Medknow Publications & Media Pvt Ltd., 2017)Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after ... -
DU 145 insan prostat kanseri hücrelerinde Hsa-Mir-8072’nin potansiyel rolü
(Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, 2019)Amaç: Çalışmamızda, insan prostat kanser hücre hattı (DU145) ve prostat normal epitel hücre hatları (RWPE) arasında miRNA ifadesinin analizini yapmak ve kanser gelişiminde olası rolünü incelemeği amaçladık. Gereçler ve ... -
The effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury
(Wiley, 2020)Axonal regeneration of the inferior alveolar nerve (IAN) is a therapeutic target for functional recovery after peripheral nerve injury. Rifampicin exerts anti-apoptotic, anti-inflammatory, and anti-oxidant effects on nerve ... -
Effects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing
(Taylor and Francis Ltd, 2017)We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and ... -
Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: The role of sirtuin 1 gene variants in human coronary atherosclerosis
(Wiley, 2015)Statins are 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and are used to reduce the risk of coronary artery disease (CAD) due to their pleiotropic effects. Recently, greater focus has been placed on the role ... -
Evaluation of in vitro anti-cancer effects of Styphnolobium japonicum root extract in human colon (HT-9), brain (U-87), and prostate (PC-3) cancer cell lines
(İstanbul University, 2020)Background and Aims: Styphnolobium japonicum (L.) Schott. (Sophora japonica) is a medicinal plant applied for various diseases, in the traditional medicine field. The evaluation of methanol extract of S. japonicum root ... -
Evaluation of the bilateral cardiac afferent distribution at the spinal and vagal ganglia by retrograde labeling
(Elsevier, 2021)The identity of sensory neurons innervating the heart tissue and the extent of information reported to the brain via these neurons are poorly understood. In order to evaluate the multidimensional distribution and abundance ... -
Evidence that activation of P2X7R does not exacerbate neuronal death after optic nerve transection and focal cerebral ischemia in mice
(Academic Press Inc Elsevier Science, 2017)Conflicting data in the literature about the function of P2X7R in survival following ischemia necessitates the conductance of in-depth studies. To investigate the impacts of activation vs inhibition of the receptor on ... -
Fare östrus siklusu'nun farklı fazlarında plin2 ve plin3 ekspresyonu
(2016)Giriş: Puberteye kadar birinci mayozun profaz evresinde bekleyen primordiyal foliküllerden birkaçı puberte ile birlikte, hormonal uyarı altında her ay tekrarlayan bir serüvene başlar. Bu süreçte ovaryumun stromal hücreleri ... -
GAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy
(Taylor and Francis, 2015)Background - Aim: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic ... -
High-resolution mapping of sensory fibers at the healthy and post-myocardial infarct whole transgenic hearts
(Wiley, 2023)The sensory nervous system is critical to maintain cardiac function. As opposed to efferent innervation, less is known about cardiac afferents. For this, we mapped the VGLUT2-expressing cardiac afferent fibers of spinal ... -
In vitro cytotoxicity evaluation of Marrubium vulgare L. methanol extract
(Marmara University, 2019)Marrubium vulgare L. (Lamiaceae) is a herbal drug used for centuries for many diseases. In this present study the plant material was acquired from commercial sources in pharma grade (PhEur 8.0) quality. The methanol extract ... -
Integrin α5β1 mediated cellular reorganization in human mesenchymal stem cells during neuronal differentiation
(International Institute of Anticancer Research, 2021)Background/Aim: Mesenchymal stem cells (MSCs) have been widely used for yielding neurons in culture to study nervous system pathologies and develop regenerative approaches. In this study, cellular rearrangements of human ...