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Understanding the differential selectivity of arrestins toward the phosphorylation state of the receptor
(American Chemical Society, 2016)
Proteins in the arrestin family exhibit a conserved structural fold that nevertheless allows for significant differences in their selectivity for G-protein coupled receptors (GPCRs) and their phosphorylation states. To ...
A GIPC1-palmitate switch modulates dopamine drd3 receptor trafficking and signaling
(Amer Soc Microbiology, 2016)
Palmitoylation is involved in several neuropsychiatric and movement disorders for which a dysfunctional signaling of the dopamine D3 receptor (Drd3) is hypothesized. Computational modeling of Drd3's homologue, Drd2, has ...