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FbpA iron storage and release are governed by periplasmic microenvironments
(Royal Society of Chemistry, 2017)
Ferric binding protein (FbpA) is part of an elaborate iron piracy mechanism evolved in Gram-negative bacteria, shuttling iron in the periplasmic space, from the outer to the cytoplasmic membrane side. We address how the ...
Perturbation-response scanning reveals key residues for allosteric control in Hsp70
(American Chemical Society, 2017)
Hsp70 molecular chaperones play-an important role in maintaining-cellular homeostasis, and are implicated in a wide array of cellular processes, including protein recovery from aggregates, cross-membrane protein translocation, ...
Perturb-Scan-Pull: A novel method facilitating conformational transitions in proteins
(American Chemical Society, 2020)
Conformational transitions in proteins facilitate precise physiological functions. Therefor; it is crucial to understand the mechanisms underlying these processes to modulate protein function. Yet, studying structural and ...
Inhibition of mutant RAS-RAF interaction by mimicking structural and dynamic properties of phosphorylated RAS
(NLM (Medline), 2022)
Undruggability of RAS proteins has necessitated alternative strategies for the development of effective inhibitors. In this respect, phosphorylation has recently come into prominence as this reversible post-translational ...