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Nanoparticle-mediated histotripsy (NMH) using perfluorohexane 'nanocones'
(Institute of Physics Publishing, 2019)Nanoparticle-mediated histotripsy (NMH) is an ultrasound treatment strategy that combines acoustically sensitive nanoparticles with histotripsy. Previous NMH studies using perfluorocarbon (PFC) nanodroplets (ND's), ∼200 ... -
Neuroprotective effects of curcumin-loaded emulsomes in a laser axotomy-induced CNS injury model
(Dove Medical Press Ltd, 2020)Purpose: Curcumin, a polyphenol isolated from the rhizomes of turmeric, holds great potential as a neuroprotective agent in addition to its anti-inflammatory and antioxidant characteristics. The poor bioavailability and ... -
A new strategy for direct solution electrospinning of phosphorylated poly(vinyl chloride)/polyethyleneimine blend in alcohol media
(Elsevier Ltd, 2023)Phosphorylated poly(vinyl chloride) (PPVC)/polyethyleneimine (PEI)-based nanofibers were produced via electrospinning in their blended solutions for the first time. For this purpose, PVC was partially converted into PVC-N3 ... -
Noninvasive ablation of prostate cancer spheroids using acoustically-activated nanodroplets
(Amer Chemical Soc, 2016)We have developed acoustically activated nanodroplets (NDs) using an amphiphilic triblock copolymer, which self-assembles and encapsulates different perfluorocarbons including perfluoropentane (PFP) and perfluorohexane ... -
A novel fontan Y-graft for interrupted inferior vena cava and azygos continuation
(Elsevier Science, 2022)Objectives: To evaluate the hemodynamicdynamic advantage of a new Fontan surgical template that is intended for complex single-ventricle patients with interrupted inferior vena cava-azygos and hemi-azygos continuation. The ... -
Novel synthetic approaches for bisnaphthalimidopropyl (BNIP) derivatives as potential anti-parasitic agents for the treatment of leishmaniasis
(MDPI, 2019)Leishmaniasis is a neglected parasitic disease that is widely seen in more than 60 countries worldwide, including Turkey and its subcontinental region. There are several chemotherapy agents for the treatment of leishmaniasis, ... -
Optimizing percutaneous pulmonary valve implantation with patient-specific 3D-printed pulmonary artery models and hemodynamic assessment
(Frontiers Media SA, 2024)Background: Percutaneous pulmonary valve implantation (PPVI) has emerged as a less invasive alternative for treating severe pulmonary regurgitation after tetralogy of Fallot (TOF) repair in patients with a native right ... -
Oxide glass formers extending persistent luminescence in Eu and Dy co-doped strontium aluminates
(Elsevier B.V., 2023)Recent work has shown that the incorporation of electrically charged, non-bridging oxygen (NBO) species into Eu and Dy co-doped Sr4Al14O25 (S4A7ED) crystal structure, in the form of BØ2O−, induces the clustering of divalent ... -
Plasmonic enhancement in PTB7-Th:PC71BM organic photovoltaics
(Elsevier B.V., 2022)Organic photovoltaics struggles with limited exciton diffusion rate and low light absorption rates. The trade-off between these deficiencies limits the thickness of the active layer around 100–200 nm range. Plasmonic light ... -
Plasmonic selection of ssDNA aptamers against fibroblast growth factor receptor
(American Chemical Society, 2019)In this work, we describe the selection of ssDNA aptamers targeting fibroblast growth factor receptor binding protein 3 K650E, which has roles in cell division, growth, and differentiation through the kinase cascade. The ... -
Proteomic study of hepatocellular carcinoma using a novel modified aptamer-based array (SOMAscan (TM)) platform
(Elsevier Science, 2017)Vascular invasion is a pathological hallmark of hepatocellular carcinoma (HCC), associated With poor prognosis; it is strongly related to the early recurrence and poor survival after curative resection. In order to determine ... -
Quantitative phase macroscopic system for label-free imaging of tissue sections
(İstanbul University, 2021)Optical microscopes are typically designed as versatile tools that are capable of imaging at various modalities with different resolutions in respective visual fields. A large extend of versatility causes increased complexity, ... -
Radiation type- and dose-specific transcriptional responses across healthy and diseased mammalian tissues
(MDPI, 2022)Ionizing radiation (IR) is a genuine genotoxic agent and a major modality in cancer treatment. IR disrupts DNA sequences and exerts mutagenic and/or cytotoxic properties that not only alter critical cellular functions but ... -
A rare ventriculoarterial connection: Double outlet of both ventricles
(Cambridge University Press, 2023)Ventriculoarterial connection is one of the important points of the segmental approach to congenital cardiac malformations. Double outlet of both ventricles is a rare form where both great arterial roots override the ... -
Real-time holographic tracking and control of microrobots
(IEEE-Inst Electrical Electronics Engineers Inc, 2017)Digital holography is used to track the three-dimensional position of a magnetic microrobot maneuvered in real time by means of an electromagnetic manipulation system. The method presented is able to process holograms at ... -
The role of positive and negative pressure on cavitation nucleation in nanodroplet-mediated histotripsy
(Iop Publishing Ltd, 2016)Nanodroplet-mediated histotripsy (NMH) is an ultrasound ablation technique combining histotripsy with acoustically sensitive perfluorocarbon (PFC) nanodroplets that can be selectively delivered to tumor cells for targeted ... -
S-layer fusion protein as a tool functionalizing emulsomes and CurcuEmulsomes for antibody binding and targeting
(Elsevier, 2015)Selective targeting of tumor cells by nanoparticle-based drug delivery systems is highly desirable because it maximizes the drug concentration at the desired target while simultaneously protecting the surrounding healthy ... -
Scattering metal waveguide based speckle-enhanced prism spectrometry
(IEEE - Institute of Electrical and Electronics Engineers, Inc., 2020)We present an optical efficiency improved speckle spectrometer where a scattering metal wave-guide is utilized along with a conventional prism spectrometer. We conducted extensive tests on 25 different scatterers, involving ... -
Selective binding of pVTK peptide-and bisphosphonate-functionalized micelles to prostate cancer cells, osteoblasts, and osteoclasts
(Andover House, Inc., 2022)This report describes the development of functionalized polymeric micelles encapsulating a chemotherapeutic agent. The results indicate the ability to achieve selective uptake into different cell populations in metastatic ... -
SELEX against whole-cell bacteria resulted in lipopolysaccharide binding aptamers
(Elsevier B.V., 2022)Nucleic acid aptamers are target-specific oligonucleotides selected from combinatorial libraries through an iterative in vitro screening process known as Systemic Evolution of Ligands by Exponential Enrichment (SELEX). In ...