Kurum Yazarı "Berk, Barkın" Makale Koleksiyonu İçin Listeleme
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Discovery of novel potent human chondrosarcoma (SW1353) inhibitors: 4-(2/3/4-pyridyl)thiazole 2-acetamide derivatives
Coşkun, Göknil Pelin; Şahin, Zafer; Erdoğan, Ömer; Çevik, Özge; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Ülgen, Mert; Demirayak, Şeref (Elsevier B.V., 2023)Chondrosarcoma is the most common cartilage sarcoma among adult patients. It is mainly observed after the degradation of chondrocytes in the case of cell stress. Unfortunately, the mortality among patients is high as a ... -
The effect of decolonization-decontamination prophylaxis versus traditional prophylaxis in orthopedic surgery in Kosovo
Ahmetaj, Donjetë; Aksoy, Nilay; Berk, Barkın (Istanbul Medipol University, 2024)This study aimed to compare empirical prophylactic treatment with decoloni-zation-decontamination prophylaxis protocol in order to reduce surgical site infections. The study was conducted in Kosovo Ortomedica Orthopedic ... -
Investigation of hidden crisis of prescription drug abuse in Turkey: Pregabalin monitoring
Badur, İsa; Bilgin Badur, Naciye; Berk, Barkın (Istanbul Medipol University, 2022)This is a cross-sectional retrospective observational national study. Abuse/misuse of the pregabalin and related parameters analyzed. Pregabalin was mostly pre-scribed by general practitioners (26.2%). Pregabalin prescribing ... -
Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors
Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Küçükkılınç, Tuba Tüylü; Demirayak, Şeref (Elsevier B.V., 2022)Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ... -
Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
Şahin, Zafer; Özhan, Yağmur; Sipahi, Hande; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Walter de Gruyter GmbH, 2022)Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with alpha-hydroxy ... -
A prospective study concerning the effect of pharmaceutical care services on patients with heart failure
Taner, Neda; Berk, Barkın (Marmara University, 2022)Objective: Heart failure (HF), caused by an abnormality in cardiac function, is the inability of heart tissue to pump blood or deliver sufficient oxygen, resulting in abnormal diastolic volume. Drug-Related Problems (DRPs) ... -
Surgical orthopedic patients’ perception of antibiotic use and antibiotic resistance
Ahmetaj, Donjete; Aksoy, Nilay; Berk, Barkın (University of Ankara, 2023)Objective: The aim of the study was to evaluate orthopedic patients' knowledge of antibiotics and antibiotic resistance. Material and Method: Patients admitted to the hospital for orthopedic surgery were given a questionnaire ... -
Synthesis and antibacterial evaluation of novel benzimidazole, benzothiazole, benzofurane, and naphtofurane derivatives of aminothiazoles
Şahin, Zafer; Tok, Büşra Işıl; Akgün, Erol; Çaşkurlu, Ayşegül; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Ankara Association of Pharmaceutical Sciences, 2022)The thiazole ring is the core of bioactive molecules that generate broad activity. These activities include anticonvulsant, antimicrobial, antituberculosis, antiviral, etc. In this work, starting from seconder/cyclic amines, ... -
Synthesis and in vitro antitumor activities of novel thioamide substituted piperazinyl-1,2,4-triazines
Şahin, Zafer; Biltekin, Sevde Nur; Ozansoy, Mehmet; Hemiş, Bervis; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Wiley, 2022)Triazines are in great interest for their potential to mimic nucleoside analog compounds. Three different isomers exist including 1,2,3-triazine, 1,3,5-triazine (s-triazine) and 1,2,4-triazine. All of these skeletons were ... -
Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds
Tay, Naime Funda; Berk, Barkın; Duran, Murat; Kayagil, İsmail; Yurttaş, Leyla; Biltekin Kaleli, Sevde Nur; Yamaç, Mustafa; Karaduman, Ayşe Betül; Demirayak, Şeref (Walter de Gruyter GmbH, 2022)In this study, novel 4-(5-((2/3/4-substituted benzyl)thio)-4-(4-substituted phenyl)-4H-1,2,4-triazol-3-yl)-2-(pyridin-3/4-yl)thiazoles were synthesized following a multi-step synthetic procedure. All the compounds were ...