ORCID "0000-0002-1079-8832" Makale Koleksiyonu için listeleme
-
Als2 silencing affects the expression of two NF-κB targeted genes via uxt in adult mouse primary spinal motor neuron culture
Çetin Ozansoy, Muzaffer Beyza; Ozansoy, Mehmet (Logos Medical Publishing, 2018)Aim: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting motor neurons. Als2 is one of the genes that cause ALS, and its mutations leads to loss of function in alsin protein. The interaction between ... -
The association between HbA1c levels, olfactory memory and cognition in normal, pre-diabetic and diabetic persons
Yuluǧ, Burak; Saatçi, Özlem; Işıklar, Aysun; Hanoǧlu, Lütfü; Kılıç, Ülkan; Ozansoy, Mehmet; Çankaya, Şeyda; Çankaya, Barış; Kılıç, Ertuğrul (Bentham Science Publ Ltd, 2020)Background and Aim: Recent data have shown that olfactory dysfunction is strongly related to Alzheimer's Disease (AD) that is often preceded by olfactory deficits suggesting that olfactory dysfunction might represent an ... -
Changes in als2 expression leads to different outcomes on the expression of two NF-kB targeted genes in N2a and C2C12 cell lines
Ozansoy, Mehmet; Ozansoy, Muzaffer Beyza (Logos Medical Publishing, 2019)Objective: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting spinal and cortical motor neurons. Motor neuron degeneration leads to progressive muscular atrophy. Als2 (alsin) is one of the causative ... -
A different view on the platelet aggregation inhibitor clopidogrel - a well-suitable anti-oedema agent in a preclinical model of brain injury?
Günal, Mehmet Yalçın; Yuluğ, Burak; Çağlayan, Berrak; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Kılıç, Ertuğrul (Czech Medical Soc, 2019)Aim: The neuroprotective effects of clopidogrel have already been shown in various experimental models. Taking into account the fact that clopidogrel is well tolerated and approved for use in various clinical settings, it ... -
The effect of rifampicin on the neuronal cell survival in primary cortical neuron culture after laser axotomy
Ozansoy, Mehmet; Coşkun, Ebru; Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Günal, Mehmet Yalçın; Bayraktaroğlu, Zübeyir; Yuluğ, Burak; Hanoğlu, Lütfü (2019)Aim: Neurodegeneration caused by the axonal injury is a widely seen phenomenon in spinal cord and traumatic brain injuries. Due to the disintegration of the synaptic connection neurotrophic factors could not be transported ... -
Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy
Yuluğ, Burak; Ozansoy, Mehmet; Alökten, Merve; Çetin Ozansoy, Muzaffer Beyza; Çankaya, Şeyda; Hanoğlu, Lütfü; Kılıç, Ülkan; Kılıç, Ertuğrul (2020)Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. ... -
N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions
Ceylan, Bahadır; Ozansoy, Mehmet; Kılıç, Ülkan; Yozgat, Yasemin; Ercan, Çilem; Yıldız, Pelin; Aslan, Turan (Taylor & Francis Ltd., 2018)Objective: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity.Methods: Twenty-eight Wistar rats were divided ... -
Neonatal neurodegeneration in alzheimer's disease transgenic mouse model
Mazi, Aişe Rümeysa; Arzuman, Ayşegül Sümeyye; Gürel, Büşra; Şahin, Betül; Tüzüner, Mete Bora; Ozansoy, Mehmet; Baykal, Ahmet Tarık (IOS Press, 2018)Alzheimer's disease (AD) is a progressive disorder characterized by a variety of molecular pathologies causing cortical dementia with a prominent memory deficit. Formation of the pathology, which begins decades before the ...