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Overview of current pharmacotherapeutic options in benign prostatic hyperplasia
(Taylor and Francis Ltd., 2023)Introduction: Benign prostatic hyperplasia (BPH) represents the histological entity of prostate cell proliferation, which inflicts a gradually increasing obstruction of the bladder outlet and is accompanied by a progressing ... -
Physiological and pharmacological roles of melatonin in the pathophysiological components of cellular injury after ischemic stroke
(NLM (Medline), 2020)Apart from its metabolic or physiological functions, melatonin has a potent cytoprotective activity in the physiological and pathological conditions. It is synthetized by the pineal gland and released into the blood ... -
Polycystic ovary syndrome: A disorder of reproductive age, its pathogenesis, and a discussion on the emerging role of herbal remedies
(Frontiers Media SA, 2022)Polycystic ovary syndrome (PCOS) is a very common, complex, and heterogeneous endocrine disorder of women that involves a combination of environmental and genetic factors. PCOS affects women of growing age particularly at ... -
Positioning Europe for the epitranscriptomics challenge
(Taylor and Francis Inc., 2018)The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. ... -
Primary whole-gland ablation for the treatment of clinically localized prostate cancer: A focal therapy society best practice statement
(Elsevier, 2023)Context: Whole-gland ablation is a feasible and effective minimally invasive treatment for localized prostate cancer (PCa). Previous systematic reviews supported evidence for favorable functional outcomes, but oncological ... -
Prostate cancer multifocality, the index lesion, and the microenvironment
(Lippincott Williams & Wilkins, 2018)Purpose of reviewMost of focal therapies has addressed index lesion as the targeted tumour focus to treat localized prostate cancer (PCa), a multifocal disease. The interaction between tumour foci and host cells creates a ... -
Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies
(Nature Publishing Group, 2019)Despite improvements in early detection and advances in treatment, patients with prostate cancer continue to die from their disease. Minimal residual disease after primary definitive treatment can lead to relapse and distant ... -
Protein and gene delivery systems for neurodegenerative disorders: Where do we stand today?
(MDPI, 2022)It has been estimated that every year, millions of people are affected by neurodegenerative disorders, which complicate their lives and their caregivers’ lives. To date, there has not been an approved pharmacological ... -
Radiological features characterising indeterminate testes masses: a systematic review and meta-analysis
(Wiley, 2023)Context: The use of scrotal ultrasonography (SUS) has increased the detection rate of indeterminate testicular masses. Defining radiological characteristics that identify malignancy may reduce the number of men undergoing ... -
Radiomics in urolithiasis: Systematic review of current applications, limitations, and future directions
(MDPI (Multidisipliner Digital Publishing Institute), 2022)Radiomics is increasingly applied to the diagnosis, management, and outcome prediction of various urological conditions. Urolithiasis is a common benign condition with a high incidence and recurrence rate. The purpose of ... -
Recommendations to balance benefits and risks of thromboprophylaxis and to avoid central venous-access devices during first-line chemotherapy in men with metastatic germ cell tumors: The European Association Of Urology Testicular Cancer Panel Position in 2021
(Elsevier, 2021)Recent randomized controlled trials have assessed the risksand benefits of thromboprophylaxis in ambulatory cancerpatients receiving chemotherapy and reported a relativerisk reduction of 30–60% in venous thromboembolic ... -
Renal autoimmunity: The role of bacterial and viral infections, an extensive review
(2022)Autoimmunity is a process by which the loss of self-tolerance results in an immune attack against the body own tissues and organs. For autoimmunity to occur, various elements serving as triggers were described by which ... -
Robotic-assisted simple prostatectomy: A systematic review
(MDPI, 2020)Contemporary minimally invasive surgical (MIS) treatment options of patients with male Lower Urinary Tract Symptoms (LUTS) in men with prostate glands >80 mL include Holmium Laser Enucleation Prostate (HoLEP), Thulium laser ... -
SARS-CoV-2 infection provoking autoimmunity
(Oxford University Press, 2023)For decades, infections have been recognized as strong stimulators of the immune system and subsequently serve as a trigger for autoimmunity and autoimmune diseases. While infection is a very broad term, infectious agents ... -
Shared pathogenicity features and sequences between EBV, SARS-CoV-2, and HLA class I molecule-binding motifs with a potential role in autoimmunity
(Springer, 2023)Epstein-Barr virus (EBV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are extraordinary in their ability to activate autoimmunity as well as to induce diverse autoimmune diseases. Here we reviewed the ... -
Sperm vitality and necrozoospermia: Diagnosis, management, and results of a global survey of clinical practice
(Korean Society for Sexual Medicine and Andrology, 2022)Sperm vitality testing is a basic semen examination that has been described in the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen from its primary edition, 40 years ago. ... -
Systematic review and meta-analysis of tocilizumab therapy versus standard of care in over 15,000 COVID-19 pneumonia patients during the first eight months of the pandemic
(MDPI, 2021)Background. Tocilizumab is an anti-IL-6 therapy widely adopted in the management of the so-called "cytokine storm" related to SARS-CoV-2 virus infection, but its effectiveness, use in relation to concomitant corticosteroid ... -
Testis-sparing surgery in adult patients with germ cell tumors: Systematic search of the literature and focused review
(Elsevier, 2023)Testis-sparing surgery (TSS) is a guideline-recommended treatment option for men with synchronous or metachronous bilateral testicular germ-cell tumor (GCT) or GCT in a solitary testicle. The tumor volume should not exceed ... -
Therapeutic role of rifampicin in Alzheimer's disease
(Wiley, 2018)Rifampicin exerts significant brain protective functions in multiple experimental models. Here we summarize the underlying mechanisms of the neuroprotective and pro-cognitive effects of rifampicin that are mediated by its ... -
Transforming urinary stone disease management by artificial intelligence-based methods: A comprehensive review
(Elsevier, 2023)Objective: To provide a comprehensive review on the existing research and evi-dence regarding artificial intelligence (AI) applications in the assessment and management of urinary stone disease.Methods: A comprehensive ...