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The single nucleotide beta-arrestin2 variant, A248T, resembles dynamical properties of activated arrestin
(TUBITAK Scientific & Technical Research Council Turkey, 2020)
beta-arrestins are responsible for termination of G protein-coupled receptor (GPCR)-mediated signaling. Association of single nucleotide variants with onset of crucial diseases has made this protein family hot targets in ...
Utilization of biased G protein-coupled receptor signaling towards development of safer and personalized therapeutics
(MDPI, 2019)
G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family. Discovery of beta-arrestin ...