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Understanding the differential selectivity of arrestins toward the phosphorylation state of the receptor
(American Chemical Society, 2016)
Proteins in the arrestin family exhibit a conserved structural fold that nevertheless allows for significant differences in their selectivity for G-protein coupled receptors (GPCRs) and their phosphorylation states. To ...
A GIPC1-palmitate switch modulates dopamine drd3 receptor trafficking and signaling
(Amer Soc Microbiology, 2016)
Palmitoylation is involved in several neuropsychiatric and movement disorders for which a dysfunctional signaling of the dopamine D3 receptor (Drd3) is hypothesized. Computational modeling of Drd3's homologue, Drd2, has ...
Genomic resources for wild populations of the house mouse, Mus musculus and its close relative Mus spretus
(Nature Publishing Group, 2016)
Wild populations of the house mouse (Mus musculus) represent the raw genetic material for the classical inbred strains in biomedical research and are a major model system for evolutionary biology. We provide whole genome ...