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Toplam kayıt 12, listelenen: 1-10
A new ratio-metric pH probe, "ThiAKS Green" for live-cell pH measurements
(Springer, 2023)
Deviation of the H+ concentration from optimum values within the organelles is closely associated with irregular cellular functions that cause the onset of various diseases. Therefore, determining subcellular pH values in ...
In silico analysis of a highly mutated gene in cancer provides insight into abnormal mRNA splicing: Splicing factor 3B subunit 1k700e mutant
(MDPI AG, 2020)
Cancer is the second leading cause of death worldwide. The etiology of the disease has remained elusive, but mutations causing aberrant RNA splicing have been considered one of the significant factors in various cancer ...
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target
(American Society for Biochemistry and Molecular Biology Inc., 2021)
Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 ...
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
(Elsevier B.V., 2022)
Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ...
A GIPC1-palmitate switch modulates dopamine drd3 receptor trafficking and signaling
(Amer Soc Microbiology, 2016)
Palmitoylation is involved in several neuropsychiatric and movement disorders for which a dysfunctional signaling of the dopamine D3 receptor (Drd3) is hypothesized. Computational modeling of Drd3's homologue, Drd2, has ...
Catalytically competent non-transforming H-RASG12P mutant provides insight into molecular switch function and GAP-independent GTPase activity of RAS
(Nature Publishing Group, 2019)
RAS mutants have been extensively studied as they are associated with development of cancer; however, H-RASG12P mutant has remained untouched since it does not lead to transformation in the cell. To the best of our knowledge, ...
Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro
(John Wiley and Sons Inc, 2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ...
The single nucleotide beta-arrestin2 variant, A248T, resembles dynamical properties of activated arrestin
(TUBITAK Scientific & Technical Research Council Turkey, 2020)
beta-arrestins are responsible for termination of G protein-coupled receptor (GPCR)-mediated signaling. Association of single nucleotide variants with onset of crucial diseases has made this protein family hot targets in ...
Utilization of biased G protein-coupled receptor signaling towards development of safer and personalized therapeutics
(MDPI, 2019)
G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family. Discovery of beta-arrestin ...
Prediction and targeting of interaction interfaces in g-rotein coupled receptor oligomers
(Bentham Science Publishers Ltd, 2018)
Background: Communication within a protein complex is mediated by physical interactions made among the protomers. Evidence for both the allosteric regulation present among the protomers of the protein oligomer and of the ...