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Toplam kayıt 150, listelenen: 91-100
Busy tone based coexistence algorithm for WRAN and WLAN systems in TV white space
(Institution of Engineering and Technology-IET, 2018)
TV White Space (TVWS) refers to frequency band reserved only for licensed terrestrial TV broadcasting and is opened to unlicensed use under regulatory conditions. While regulations protect licensed systems from interference, ...
A review of computational drug repositioning: Strategies, approaches, opportunities, challenges, and directions
(BMC, 2020)
Drug repositioning is the process of identifying novel therapeutic potentials for existing drugs and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an important role in optimizing the ...
Inhibition of AKT signaling alters beta IV spectrin distribution at the AIS and increases neuronal excitability
(Frontiers Media S.A., 2021)
The axon initial segment (AIS) is a highly regulated subcellular domain required for neuronal firing. Changes in the AIS protein composition and distribution are a form of structural plasticity, which powerfully regulates ...
Effective induction of gene regulatory networks using a novel recommendation method
(Inderscience Enterprises Ltd., 2019)
In this paper, we introduce a method based on recommendation systems to predict the structure of Gene Regulatory Networks (GRNs) making use of data from multiple sources. Our method is based on collaborative filtering ...
Modulation of protein-protein interactions for the development of effective therapeutics - from a joint perspective of experiment and computation
(Bentham Science Publishers B.V., 2018)
Many proteins present in living organisms act as obligate oligomers – that is to say - they require other protein partners to function properly. Oligomerization does not only lead to the formation of physical interactions, ...
Tweet and user validation with supervised feature ranking and rumor classification
(Springer, 2022)
Filtering fake news from social network posts and detecting social network users who are responsible for generating and propagating these rumors have become two major issues with the increased popularity of social networking ...
Computational approaches in antibody-drug conjugate optimization for targeted cancer therapy
(Bentham Science Publishers Ltd, 2018)
Cancer has become one of the main leading causes of morbidity and mortality worldwide. One of the critical drawbacks of current cancer therapeutics has been the lack of the target-selectivity, as these drugs should have ...
Perturbation-response scanning reveals key residues for allosteric control in Hsp70
(American Chemical Society, 2017)
Hsp70 molecular chaperones play-an important role in maintaining-cellular homeostasis, and are implicated in a wide array of cellular processes, including protein recovery from aggregates, cross-membrane protein translocation, ...
Utilization of biased G protein-coupled receptor signaling towards development of safer and personalized therapeutics
(MDPI, 2019)
G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family. Discovery of beta-arrestin ...
Prediction and targeting of interaction interfaces in g-rotein coupled receptor oligomers
(Bentham Science Publishers Ltd, 2018)
Background: Communication within a protein complex is mediated by physical interactions made among the protomers. Evidence for both the allosteric regulation present among the protomers of the protein oligomer and of the ...