ORCID "0000-0001-5950-3436" Computer Engineering için listeleme
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Catalytically competent non-transforming H-RASG12P mutant provides insight into molecular switch function and GAP-independent GTPase activity of RAS
Metehan, İlter; Şensoy, Özge (Nature Publishing Group, 2019)RAS mutants have been extensively studied as they are associated with development of cancer; however, H-RASG12P mutant has remained untouched since it does not lead to transformation in the cell. To the best of our knowledge, ... -
Computational approaches in antibody-drug conjugate optimization for targeted cancer therapy
Melo, Rita; Lemos, Agostinho; Preto, Antonio Jose; Almeida, Jose Guilherme; Correia, Joao D. G.; Şensoy, Özge; Moreira, Irina Sousa (Bentham Science Publishers Ltd, 2018)Cancer has become one of the main leading causes of morbidity and mortality worldwide. One of the critical drawbacks of current cancer therapeutics has been the lack of the target-selectivity, as these drugs should have ... -
Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS-CoV-2 protease 3CLpro
Ferreira, Juliana C.; Fadl, Samar; İlter, Metehan; Pekel, Hanife; Rezgui, Rachid; Şensoy, Özge; Rabeh, Wael M. (John Wiley and Sons Inc, 2021)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for coronavirus disease 2019 (COVID-19), one of the most challenging global pandemics of the modern era. Potential treatment strategies against ... -
FbpA iron storage and release are governed by periplasmic microenvironments
Şensoy, Özge; Atılgan, Ali Rana; Atılgan, Canan (Royal Society of Chemistry, 2017)Ferric binding protein (FbpA) is part of an elaborate iron piracy mechanism evolved in Gram-negative bacteria, shuttling iron in the periplasmic space, from the outer to the cytoplasmic membrane side. We address how the ... -
A GIPC1-palmitate switch modulates dopamine drd3 receptor trafficking and signaling
Arango-Lievano, Margarita; Şensoy, Özge; Borie, Amelie; Corbani, Maithe; Guillon, Gilles; Sokoloff, Pierre; Weinstein, Harel; Jeanneteau, Freddy (Amer Soc Microbiology, 2016)Palmitoylation is involved in several neuropsychiatric and movement disorders for which a dysfunctional signaling of the dopamine D3 receptor (Drd3) is hypothesized. Computational modeling of Drd3's homologue, Drd2, has ... -
In silico analysis of a highly mutated gene in cancer provides insight into abnormal mRNA splicing: Splicing factor 3B subunit 1k700e mutant
Samy, Asmaa; Süzek, Barış Ethem; Özdemir, Mehmet Kemal; Şensoy, Özge (MDPI AG, 2020)Cancer is the second leading cause of death worldwide. The etiology of the disease has remained elusive, but mutations causing aberrant RNA splicing have been considered one of the significant factors in various cancer ... -
Inhibition of SARS-CoV-2 main protease: A repurposing study that targets the dimer interface of the protein
Pekel, Hanife; İlter, Metehan; Şensoy, Özge (Taylor and Francis Ltd., 2022)Coronavirus disease-2019 (COVID-19) was firstly reported in Wuhan, China, towards the end of 2019, and emerged as a pandemic. The spread and lethality rates of the COVID-19 have ignited studies that focus on the development ... -
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target
Ferreira, Juliana C.; Khrbtli, Abdul Rahman; Shetler, Cameron L.; Mansoor, Samman; Ali, Liaqat; Şensoy, Özge; Rabeh, Wael M. (American Society for Biochemistry and Molecular Biology Inc., 2021)Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 ... -
Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase
Pekel, Hanife; Güzel, Mustafa; Şensoy, Özge (Wiley, 2022)Farnesyltransferase (FTase) is a heterodimeric enzyme, which catalyzes covalent attachment of the farnesyl group to target proteins, thus coordinating their trafficking in the cell. FTase has been demonstrated to be highly ... -
Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
Mansoor, Samman; Kayık, Gülru; Durdağı, Serdar; Şensoy, Özge (Elsevier B.V., 2022)Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies ... -
Modulation of protein-protein interactions for the development of effective therapeutics - from a joint perspective of experiment and computation
Moreira, Irina Sousa; Şensoy, Özge (Bentham Science Publishers B.V., 2018)Many proteins present in living organisms act as obligate oligomers – that is to say - they require other protein partners to function properly. Oligomerization does not only lead to the formation of physical interactions, ... -
A new ratio-metric pH probe, "ThiAKS Green" for live-cell pH measurements
Akyol, Ali; Baykal, Doruk; Akdağ, Akın; Şensoy, Özge; Son, Cağdaş Devrim (Springer, 2023)Deviation of the H+ concentration from optimum values within the organelles is closely associated with irregular cellular functions that cause the onset of various diseases. Therefore, determining subcellular pH values in ... -
Perturb-Scan-Pull: A novel method facilitating conformational transitions in proteins
Jalalypour, Farzaneh; Şensoy, Özge; Atılgan, Canan (American Chemical Society, 2020)Conformational transitions in proteins facilitate precise physiological functions. Therefor; it is crucial to understand the mechanisms underlying these processes to modulate protein function. Yet, studying structural and ... -
Perturbation-response scanning reveals key residues for allosteric control in Hsp70
Penkler, David; Şensoy, Özge; Atılgan, Canan; Taştan Bishop, Özlem (American Chemical Society, 2017)Hsp70 molecular chaperones play-an important role in maintaining-cellular homeostasis, and are implicated in a wide array of cellular processes, including protein recovery from aggregates, cross-membrane protein translocation, ... -
Prediction and targeting of interaction interfaces in g-rotein coupled receptor oligomers
Schiedel, Anke C.; Köse, Meryem; Barreto, Carlos; Bueschbell, Beatriz; Morra, Giulia; Şensoy, Özge; Moreira, Irina Sousa (Bentham Science Publishers Ltd, 2018)Background: Communication within a protein complex is mediated by physical interactions made among the protomers. Evidence for both the allosteric regulation present among the protomers of the protein oligomer and of the ... -
The single nucleotide beta-arrestin2 variant, A248T, resembles dynamical properties of activated arrestin
Şensoy, Özge (TUBITAK Scientific & Technical Research Council Turkey, 2020)beta-arrestins are responsible for termination of G protein-coupled receptor (GPCR)-mediated signaling. Association of single nucleotide variants with onset of crucial diseases has made this protein family hot targets in ... -
Synthesis, structural investigations, DNA/BSA interactions, molecular docking studies, and anticancer activity of a new 1,4-disubstituted 1,2,3-triazole derivative
Göktürk, Tolga; Sakallı Çetin, Esin; Hökelek, Tuncer; Pekel, Hanife; Şensoy, Özge; Aksu, Ebru Nur; Güp, Ramazan (American Chemical Society, 2023)We report herein a new 1,2,3-triazole derivative, namely, 4-(( 1-( 3,4-dichlorophenyl)-1H-1,2,3- triazol- 4-yl)methoxy)-2-hydroxybenzaldehyde, which was synthesized by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). ... -
Understanding the differential selectivity of arrestins toward the phosphorylation state of the receptor
Şensoy, Özge; Moreira, Irina Sousa; Morra, Giulia (American Chemical Society, 2016)Proteins in the arrestin family exhibit a conserved structural fold that nevertheless allows for significant differences in their selectivity for G-protein coupled receptors (GPCRs) and their phosphorylation states. To ... -
Utilization of biased G protein-coupled receptor signaling towards development of safer and personalized therapeutics
İlter, Metehan; Mansoor, Samman; Şensoy, Özge (MDPI, 2019)G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family. Discovery of beta-arrestin ...