dc.contributor.author | Tüken, Murat | |
dc.contributor.author | Kiremit, Murat Can | |
dc.contributor.author | Şerefoğlu, Ege Can | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:04:26Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:04:26Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Tüken, M., Kiremit, Murat C. ve Şerefoğlu, Ege C. (2016). On-demand modafinil improves ejaculation time and patient-reported outcomes in men with lifelong premature ejaculation. Urology, 94. 139-142. https://dx.doi.org/10.1016/j.urology.2016.04.036 | en_US |
dc.identifier.issn | 0090-4295 | |
dc.identifier.issn | 1527-9995 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.urology.2016.04.036 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/4051 | |
dc.description | WOS: 000383696400037 | en_US |
dc.description | PubMed ID: 27151339 | en_US |
dc.description.abstract | OBJECTIVE To evaluate the effects of modafinil on the intravaginal ejaculatory latency time (IELT) and patient-reported outcomes in patients with lifelong premature ejaculation (PE). PATIENTS AND METHODS Treatment-naive lifelong PE patients were included in this proof-of-concept study. Self-estimated IELTs of the patients were recorded and the Premature Ejaculation Profile (PEP) questionnaire was administered before the initiation of on-demand modafinil 100 mg treatment. At the end of 1 month of treatment, self-estimated IELTs were recorded again, along with posttreatment PEP outcomes. RESULTS Overall, 55 lifelong PE patients with a mean age of 35.07 +/- 7.80 (range: 22-58) years were enrolled. Modafinil treatment modestly increased the mean IELT at the end of 1 month (24.82 +/- 16.10 seconds vs 49.82 +/- 31.46 seconds, P =.0001). Moreover, at the end of 1 month, patients reported in the PEP questionnaire better control over ejaculation (0.75 +/- 0.67 vs 1.35 +/- 0.91, P =.0001), improved satisfaction with sexual intercourse (0.98 +/- 0.78 vs 1.40 +/- 0.85, P =.0001), lesser personal distress (0.42 +/- 0.69 vs 0.89 +/- 1.01, P =.0001), and reduced interpersonal difficulty (1.69 +/- 1.48 vs 1.95 +/- 1.47, P =.0001). CONCLUSION In an uncontrolled proof-of-concept study of men with treatment-naive lifelong PE where IELT was self-reported without a stopwatch, modest improvements of both IELT and patient-reported outcome measures were observed. Future controlled clinical trials are necessary to confirm these findings. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | On-Demand Modafinil | en_US |
dc.subject | Improves Ejaculation | en_US |
dc.subject | Lifelong Premature Ejaculation | en_US |
dc.title | On-demand modafinil improves ejaculation time and patient-reported outcomes in men with lifelong premature ejaculation | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Urology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 94 | en_US |
dc.identifier.startpage | 139 | en_US |
dc.identifier.endpage | 142 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.urology.2016.04.036 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q1 | en_US |