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dc.contributor.authorTokmak, Mehmet
dc.contributor.authorŞehitoğlu, Müserref Hilal
dc.contributor.authorYüksel, Yasemin
dc.contributor.authorGüven, Mustafa
dc.contributor.authorAkman, Tarık
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorYaka, Umut
dc.contributor.authorGömleksiz, Cengiz
dc.contributor.authorAlbayrak, Serdar Baki
dc.contributor.authorCoşar, Murat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:04:13Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:04:13Z
dc.date.issued2017en_US
dc.identifier.citationTokmak, M., Şehitoğlu, M. H., Yüksel, Y., Güven, M., Akman, T., Aras, A. ... Coşar, M. (2017). The axon protective effects of syringic acid on ischemia/ereperfusion injury in a rat sciatic nerve model. Turkish Neurosurgery, 27(1), 124-132. https://dx.doi.org/10.5137/1019-5149.JTN.14656-15.5en_US
dc.identifier.issn1019-5149
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.14656-15.5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4015
dc.descriptionWOS: 000392042000017en_US
dc.descriptionPubMed ID: 27593755en_US
dc.description.abstractAIM: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. MATERIAL and METHODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. lschemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. RESULTS: lschemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. CONCLUSION: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.en_US
dc.language.isoengen_US
dc.publisherTurkish Neurosurgical Societyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAxonen_US
dc.subjectSciatic Nerveen_US
dc.subjectSyringic Aciden_US
dc.subjectMethylprednisoloneen_US
dc.subjectReperfusionen_US
dc.subjectMalondialdehydeen_US
dc.subjectNuclear Respiratory Factor 1en_US
dc.subjectSuperoxide Dismutaseen_US
dc.titleThe axon protective effects of syringic acid on ischemia/ereperfusion injury in a rat sciatic nerve modelen_US
dc.typearticleen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalıen_US
dc.authorid0000-0003-1367-1121en_US
dc.identifier.volume27en_US
dc.identifier.issue1en_US
dc.identifier.startpage124en_US
dc.identifier.endpage132en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5137/1019-5149.JTN.14656-15.5en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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