The axon protective effects of syringic acid on ischemia/ereperfusion injury in a rat sciatic nerve model
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessTarih
2017Yazar
Tokmak, MehmetŞehitoğlu, Müserref Hilal
Yüksel, Yasemin
Güven, Mustafa
Akman, Tarık
Aras, Adem Bozkurt
Yaka, Umut
Gömleksiz, Cengiz
Albayrak, Serdar Baki
Coşar, Murat
Üst veri
Tüm öğe kaydını gösterKünye
Tokmak, M., Şehitoğlu, M. H., Yüksel, Y., Güven, M., Akman, T., Aras, A. ... Coşar, M. (2017). The axon protective effects of syringic acid on ischemia/ereperfusion injury in a rat sciatic nerve model. Turkish Neurosurgery, 27(1), 124-132. https://dx.doi.org/10.5137/1019-5149.JTN.14656-15.5Özet
AIM: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. MATERIAL and METHODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. lschemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. RESULTS: lschemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. CONCLUSION: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
WoS Q Kategorisi
Q4Scopus Q Kategorisi
Q3Kaynak
Turkish NeurosurgeryCilt
27Sayı
1Bağlantı
https://dx.doi.org/10.5137/1019-5149.JTN.14656-15.5https://hdl.handle.net/20.500.12511/4015