dc.contributor.author | Aytürk, Nilüfer | |
dc.contributor.author | Fırat, Tülin | |
dc.contributor.author | Kükner, Aysel | |
dc.contributor.author | Özoğul, Candan | |
dc.contributor.author | Töre, Fatma | |
dc.contributor.author | Kandıralı, İsmail Engin | |
dc.contributor.author | Yılmaz, Bayram | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:03:48Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:03:48Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Aytürk, N., Fırat, T., Kükner, A., Özoğul, C., Töre, F., Kandıralı, İ. E. ... Yılmaz, B. (2017). The effect of kisspeptin on spermatogenesis and apoptosis in rats. Turkish Journal of Medical Sciencesa, 47(1), 334-342. https://dx.doi.org/10.3906/sag-1505-69 | en_US |
dc.identifier.issn | 1300-0144 | |
dc.identifier.issn | 1303-6165 | |
dc.identifier.uri | https://dx.doi.org/10.3906/sag-1505-69 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3945 | |
dc.description | WOS: 000395632600048 | en_US |
dc.description | PubMed ID: 28263511 | en_US |
dc.description.abstract | Background/aim: To study the effect of kisspeptin, a gonadotropin release stimulator, on the testicular tissue of the rat. Materials and methods: Four groups were formed as follows: control, Kiss-10 50 nmol administration for 1 day, Kiss-10 administration for 13 days, and one last group kept for 7 days following Kiss-10 applied for 13 days. Testicular tissues were stained with hematoxylineosin, periodic acid Schiff, Masson trichrome staining, terminal deoxynucleotidyl transferased UTP nick-end labeling, and Ki-67 immune staining. Serum testosterone levels were determined. Results: Serum testosterone level increased following acute application, while it was reduced by chronic treatment. Spermatogenic cells as stained by Ki-67 and TUNEL increased in the treated groups compared to the controls. Following a 7-day rest after treatment, a decrease in testosterone levels and Ki-67-stained cell numbers and an increase in TUNEL-stained cells were observed. Leydig cells showed increased vacuolization in the Kiss-1 group. Leydig cell vacuolization continued in the Kiss (13) group and was reduced in the Kiss (13 + 7) group. Conclusion: Kiss-10 increased spermatogenic cell proliferation, while testosterone level and proliferation decreased and apoptosis increased during the waiting period. | en_US |
dc.description.sponsorship | Abant Izzet Baysal University Scientific Research Foundation [2010.08.01.348] | en_US |
dc.description.sponsorship | This study was supported by Abant Izzet Baysal University Scientific Research Foundation (2010.08.01.348). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | TUBITAK Scıentıfıc & Technical Research Council Turkey | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Kisspeptin | en_US |
dc.subject | Spermatogenesis | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Leydig Cells | en_US |
dc.title | The effect of kisspeptin on spermatogenesis and apoptosis in rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Turkish Journal of Medical Sciencesa | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 47 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 334 | en_US |
dc.identifier.endpage | 342 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.3906/sag-1505-69 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |