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dc.contributor.authorAytürk, Nilüfer
dc.contributor.authorFırat, Tülin
dc.contributor.authorKükner, Aysel
dc.contributor.authorÖzoğul, Candan
dc.contributor.authorTöre, Fatma
dc.contributor.authorKandıralı, İsmail Engin
dc.contributor.authorYılmaz, Bayram
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:48Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:48Z
dc.date.issued2017en_US
dc.identifier.citationAytürk, N., Fırat, T., Kükner, A., Özoğul, C., Töre, F., Kandıralı, İ. E. ... Yılmaz, B. (2017). The effect of kisspeptin on spermatogenesis and apoptosis in rats. Turkish Journal of Medical Sciencesa, 47(1), 334-342. https://dx.doi.org/10.3906/sag-1505-69en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1505-69
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3945
dc.descriptionWOS: 000395632600048en_US
dc.descriptionPubMed ID: 28263511en_US
dc.description.abstractBackground/aim: To study the effect of kisspeptin, a gonadotropin release stimulator, on the testicular tissue of the rat. Materials and methods: Four groups were formed as follows: control, Kiss-10 50 nmol administration for 1 day, Kiss-10 administration for 13 days, and one last group kept for 7 days following Kiss-10 applied for 13 days. Testicular tissues were stained with hematoxylineosin, periodic acid Schiff, Masson trichrome staining, terminal deoxynucleotidyl transferased UTP nick-end labeling, and Ki-67 immune staining. Serum testosterone levels were determined. Results: Serum testosterone level increased following acute application, while it was reduced by chronic treatment. Spermatogenic cells as stained by Ki-67 and TUNEL increased in the treated groups compared to the controls. Following a 7-day rest after treatment, a decrease in testosterone levels and Ki-67-stained cell numbers and an increase in TUNEL-stained cells were observed. Leydig cells showed increased vacuolization in the Kiss-1 group. Leydig cell vacuolization continued in the Kiss (13) group and was reduced in the Kiss (13 + 7) group. Conclusion: Kiss-10 increased spermatogenic cell proliferation, while testosterone level and proliferation decreased and apoptosis increased during the waiting period.en_US
dc.description.sponsorshipAbant Izzet Baysal University Scientific Research Foundation [2010.08.01.348]en_US
dc.description.sponsorshipThis study was supported by Abant Izzet Baysal University Scientific Research Foundation (2010.08.01.348).en_US
dc.language.isoengen_US
dc.publisherTUBITAK Scıentıfıc & Technical Research Council Turkeyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKisspeptinen_US
dc.subjectSpermatogenesisen_US
dc.subjectApoptosisen_US
dc.subjectLeydig Cellsen_US
dc.titleThe effect of kisspeptin on spermatogenesis and apoptosis in ratsen_US
dc.typearticleen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.identifier.volume47en_US
dc.identifier.issue1en_US
dc.identifier.startpage334en_US
dc.identifier.endpage342en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3906/sag-1505-69en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ3en_US


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