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The effect of kisspeptin on spermatogenesis and apoptosis in rats

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info:eu-repo/semantics/openAccess

Date

2017

Author

Aytürk, Nilüfer
Fırat, Tülin
Kükner, Aysel
Özoğul, Candan
Töre, Fatma
Kandıralı, İsmail Engin
Yılmaz, Bayram

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Aytürk, N., Fırat, T., Kükner, A., Özoğul, C., Töre, F., Kandıralı, İ. E. ... Yılmaz, B. (2017). The effect of kisspeptin on spermatogenesis and apoptosis in rats. Turkish Journal of Medical Sciencesa, 47(1), 334-342. https://dx.doi.org/10.3906/sag-1505-69

Abstract

Background/aim: To study the effect of kisspeptin, a gonadotropin release stimulator, on the testicular tissue of the rat. Materials and methods: Four groups were formed as follows: control, Kiss-10 50 nmol administration for 1 day, Kiss-10 administration for 13 days, and one last group kept for 7 days following Kiss-10 applied for 13 days. Testicular tissues were stained with hematoxylineosin, periodic acid Schiff, Masson trichrome staining, terminal deoxynucleotidyl transferased UTP nick-end labeling, and Ki-67 immune staining. Serum testosterone levels were determined. Results: Serum testosterone level increased following acute application, while it was reduced by chronic treatment. Spermatogenic cells as stained by Ki-67 and TUNEL increased in the treated groups compared to the controls. Following a 7-day rest after treatment, a decrease in testosterone levels and Ki-67-stained cell numbers and an increase in TUNEL-stained cells were observed. Leydig cells showed increased vacuolization in the Kiss-1 group. Leydig cell vacuolization continued in the Kiss (13) group and was reduced in the Kiss (13 + 7) group. Conclusion: Kiss-10 increased spermatogenic cell proliferation, while testosterone level and proliferation decreased and apoptosis increased during the waiting period.

WoS Q Kategorisi

Q4

xmlui.dri2xhtml.METS-1.0.item-scopusquality

Q3

Source

Turkish Journal of Medical Sciencesa

Volume

47

Issue

1

URI

https://dx.doi.org/10.3906/sag-1505-69
https://hdl.handle.net/20.500.12511/3945

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  • Makale Koleksiyonu [3452]
  • PubMed İndeksli Yayınlar Koleksiyonu [3764]
  • Scopus İndeksli Yayınlar Koleksiyonu [5808]
  • TR-Dizin İndeksli Yayınlar Koleksiyonu [2168]
  • WoS İndeksli Yayınlar Koleksiyonu [5978]



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