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dc.contributor.authorBilici, Ahmet
dc.contributor.authorSonkaya, Alper
dc.contributor.authorErcan, Şerif
dc.contributor.authorUstaalioğlu, Bala Başak Öven
dc.contributor.authorŞeker, Mesut
dc.contributor.authorAliustaoǧlu, Mehmet
dc.contributor.authorOrçun, Asuman
dc.contributor.authorGümüş, Mahmut
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:24Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:24Z
dc.date.issued2015en_US
dc.identifier.citationBilici, A. E., Sonkaya, A., Ercan, Ş., Ustaalioğlu, B. B. Ö., Şeker, M., Aliustaoǧlu, M. ...Gümüş, M. (2015). The changing of serum vitamin B-12 and homocysteine levels after gastrectomy in patients with gastric cancer: do they associate with clinicopathological factors? Tumor Biology, 36(2), 823-828. https://dx.doi.org/10.1007/s13277-014-2705-3en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.urihttps://dx.doi.org/10.1007/s13277-014-2705-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3868
dc.descriptionWOS: 000350478200042en_US
dc.descriptionPubMed ID: 25296737en_US
dc.description.abstractAfter total (TG) or distal subtotal gastrectomy (DG), patients are at high risk of vitamin B-12 (vit-B-12) deficiency, which results in elevation of homocysteine levels. The changing of serum vit-B-12 and homocysteine levels in patients with gastric cancer is not well known. Seventy-two patients with gastric cancer who had undergone currative gastrectomy and 50 healthy controls were included. Serum vit-B-12 and homocysteine levels were analyzed in gastric cancer patients. In addition, these parameters were compared with those of healthy control subjects. While serum vit-B-12 levels in gastrectomized patients were significantly lower than that of healthy controls (221.8 +/- 125.6 pg/mL vs. 309.9 +/- 174.3 pg/mL, p = 0.002), homocysteine levels were significantly higher in patients with gastric cancer (14.2 +/- 6.7 mu mol/L vs. 12.5 +/- 6.1 mu mol/L, p = 0.016). Mean serum folate level was found to be high in healthy controls (7.3 ng/mL) compared to patients (9.2 ng/mL, p = 0.027). Out of 72 patients, 40 patients (55.6 %) with gastric cancer developed vit-B-12 deficiency after gastrectomy. Vit-B-12 deficiency was found to be related with gastrectomy type (p = 0.02) and homocysteine levels (p = 0.014). In patients who underwent TG, the incidence of vit-B-12 deficiency was significantly higher compared with those with DG (67.5 vs. 32.5 %). In addition, serum vit-B-12 level in patients with DG was significantly higher than that of patients with TG (248.3 +/- 122.0 pg/mL vs. 200.8 +/- 126.7 pg/mL, p = 0.041), whereas homocysteine levels were significantly lower in DG group compared with TG group (12.1 +/- 6.1 mu mol/L vs. 15.8 +/- 6.9 mu mol/L, p = 0.014). A logistic regression analysis showed that the extent of gastrectomy was found to be an independent factor for predicting the occurrence of vit-B-12 deficiency (p < 0.001, odds ratio 1.38). Our results showed that cumulative vit-B-12 deficiency rate was significantly higher after TG compared with that after DG, while homocysteine levels were significantly higher in TG group compared with DG group. The extent of gastrectomy was found to be an independent factor for predicting the occurrence of vit-B-12 deficiency. Vit-B-12 deficiency and hyperhomocysteinemia are imperious clinical situation for patients with gastric cancer after surgery. Hence, both preoperative and regular postoperative monitoring of vit-B-12 and homocysteine levels for all gastrectomized patients with gastric cancer are important and necessary for early detection and prevention of vit-B-12 deficiency and hyperhomocysteinemia as a risk factor for cardiovascular diseases.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectVitamin B-12en_US
dc.subjectHomocysteineen_US
dc.subjectGastrectomyen_US
dc.subjectGastric Canceren_US
dc.titleThe changing of serum vitamin B-12 and homocysteine levels after gastrectomy in patients with gastric cancer: do they associate with clinicopathological factors?en_US
dc.typearticleen_US
dc.relation.journalTumor Biologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume36en_US
dc.identifier.issue2en_US
dc.identifier.startpage823en_US
dc.identifier.endpage828en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s13277-014-2705-3en_US


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