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dc.contributor.authorUygun, Vedat
dc.contributor.authorDaloğlu, Hayriye
dc.contributor.authorIrmak Öztürkmen, Seda
dc.contributor.authorDöşemeci, Levent
dc.contributor.authorKarasu, Gülsün
dc.contributor.authorHazar, Volkan
dc.contributor.authorYeşilipek, Akif
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:20Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:20Z
dc.date.issued2016en_US
dc.identifier.citationUygun, V., Daloğlu, H., Irmak Öztürkmen, S., Döşemeci, L., Karasu, G., Hazar, V. ... Yeşilipek, A. (2016). Extracorporeal photopheresis did not prevent the development of an autoimmune disease: myasthenia gravis. Transfusion, 56(12), 3081-3085. https://dx.doi.org/10.1111/trf.13821en_US
dc.identifier.issn0041-1132
dc.identifier.issn1537-2995
dc.identifier.urihttps://dx.doi.org/10.1111/trf.13821
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3853
dc.descriptionWOS: 000390578300026en_US
dc.descriptionPubMed ID: 27612294en_US
dc.description.abstractBACKGROUNDMyasthenia gravis (MG) is a neuromuscular disorder characterized by an autoimmune defect in the neuromuscular junction. In most patients, the autoimmune attack is mediated by antibodies against the acetylcholine receptor (AChR) on the postsynaptic membrane. Deficient immunoregulation, including regulatory T cells, is consistently observed. Extracorporeal photopheresis (ECP) leads to the induction of regulatory T cells that mediate immunologic tolerance in autoimmune diseases; however, the data regarding MG are very limited. CASE REPORTHere, we report a patient who, during ongoing ECP therapy for his severe, refractory, chronic graft-versus-host disease (cGVHD), developed MG, although he responded very well to ECP, as indicated by the lowering of his chronic cGVHD severity grade to moderate. RESULTSDespite receiving ECP, our patient developed MG, which was resistant to treatment and required intensive care unit support. CONCLUSIONSClose surveillance is required when ECP is planned as one of the treatment alternatives in myasthenia gravis that develop in cGVHD.en_US
dc.language.isoengen_US
dc.publisherWiley-Blackwellen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutoimmuneen_US
dc.subjectMyasthenia Gravis (MG)en_US
dc.subjectChronic Graft-Versus-Host Disease (cGVHD)en_US
dc.titleExtracorporeal photopheresis did not prevent the development of an autoimmune disease: myasthenia gravisen_US
dc.typearticleen_US
dc.relation.journalTransfusionen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.authorid0000-0002-1407-2334en_US
dc.identifier.volume56en_US
dc.identifier.issue12en_US
dc.identifier.startpage3081en_US
dc.identifier.endpage3085en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/trf.13821en_US


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