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dc.contributor.authorKarabulut, Seda
dc.contributor.authorAksünger, Özlem
dc.contributor.authorAta, Can
dc.contributor.authorSağıroğlu, Yusuf
dc.contributor.authorKeskin, İlknur
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:13Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:13Z
dc.date.issued2018en_US
dc.identifier.citationKarabulut, S., Aksünger, Ö., Ata, C., Sağıroğlu, Y. ve Keskin, İ. (2018). Artificial oocyte activation with calcium ionophore for frozen sperm cycles. Systems Biology in Reproductive Medicine, 64(5), 381-388. https://dx.doi.org/10.1080/19396368.2018.1452311en_US
dc.identifier.issn1939-6368
dc.identifier.issn1939-6376
dc.identifier.urihttps://dx.doi.org/10.1080/19396368.2018.1452311
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3829
dc.descriptionWOS: 000445003100007en_US
dc.descriptionPubMed ID: 29620419en_US
dc.description.abstractFertilization problems are the major problems that may be faced in 30-55% of the patients during an intracytoplasmic sperm injection (ICSI) cycle. A successful oocyte activation depends on factors related to both sperm and oocyte, and one of the important factors that mediates the process is Ca2+ concentration within the oocyte. Artificial oocyte activation (AOA) is a method used for fertilization problems that commonly involve the usage of Ca2+ ionophores and is usually used in problems such as total fertilization failure (TFF) and globozoospermia. The aim of the present study was to investigate possible effects of AOA for different groups of patients with fertilization failure. Four groups of patients (previous TFF, low oocyte number, severe sperm quality, and frozen sperm (FS) group) that underwent ICSI with AOA were included in the study. All groups had similar control groups with same indications except TFF, where AOA was not performed. Fertilization rates were significantly higher in the TFF group than those observed in other AOA groups. Fertilization rates and quality of embryos observed in the remaining AOA groups were higher than those of the controls, which were statistically insignificant. Prgenancy rates were higher in all AOA groups compared to the controls, although the differences were significant in FS group only. Quality of embryos and pregnancy rates were lower in the TFF group compared to the remaining AOA groups indicating possible concomitant problems. Fertilization rates, quality of embryos and pregnancy rates seemed to be increased in all indication groups suggesting that not only TFF patients but also a wide variety of patients with different indications may benefit from AOA.Abbreviations: ICSI: Intracytoplasmic sperm injection; ARTs: Assisted reproductive techniques; Ca: Calcium; AOA: Artificial oocyte activation; TFF: Total fertilization failures; OAT: Oligoasthenoteratozoospemia; IVF: In vitro fertilization; SOAT: Severe OAT; LON: Low ooctye number; FS: Frozen sperm; hCG: human chorionic gonadotrophin; PVP: polyvinylpyrrolidone; HSA: human serum albuminen_US
dc.language.isoengen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArtificial Oocyte Activationen_US
dc.subjectICSIen_US
dc.subjectFertilizationen_US
dc.subjectSpermen_US
dc.titleArtificial oocyte activation with calcium ionophore for frozen sperm cyclesen_US
dc.typearticleen_US
dc.relation.journalSystems Biology in Reproductive Medicineen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0003-3302-5004en_US
dc.authorid0000-0002-7059-1884en_US
dc.identifier.volume64en_US
dc.identifier.issue5en_US
dc.identifier.startpage381en_US
dc.identifier.endpage388en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1080/19396368.2018.1452311en_US


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