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dc.contributor.authorDiken, Elif
dc.contributor.authorÖzer, Tuğba
dc.contributor.authorArıkan, Muzaffer
dc.contributor.authorEmrence, Zeliha
dc.contributor.authorToksoy Öner, Ebru
dc.contributor.authorÜstek, Duran
dc.contributor.authorArğa, Kazım Yalçın
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:07Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:07Z
dc.date.issued2015en_US
dc.identifier.citationDiken, E., Özer, T., Arıkan, M., Emrence, Z., Toksoy Öner, E., Üstek, D. ve Arğa, K. Y. (2015). Genomic analysis reveals the biotechnological and industrial potential of levan producing halophilic extremophile, Halomonas smyrnensis AAD6T. SpringerPlus, 4. https://dx.doi.org/10.1186/s40064-015-1184-3en_US
dc.identifier.issn2193-1801
dc.identifier.urihttps://dx.doi.org/10.1186/s40064-015-1184-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3808
dc.descriptionWOS: 000359435700004en_US
dc.descriptionPubMed ID: 26251777en_US
dc.description.abstractHalomonas smyrnensis AAD6T is a gram negative, aerobic, and moderately halophilic bacterium, and is known to produce high levels of levan with many potential uses in foods, feeds, cosmetics, pharmaceutical and chemical industries due to its outstanding properties. Here, the whole-genome analysis was performed to gain more insight about the biological mechanisms, and the whole-genome organization of the bacterium. Industrially crucial genes, including the levansucrase, were detected and the genome-scale metabolic model of H. smyrnensis AAD6T was reconstructed. The bacterium was found to have many potential applications in biotechnology not only being a levan producer, but also because of its capacity to produce Pel exopolysaccharide, polyhydroxyalkanoates, and osmoprotectants. The genomic information presented here will not only provide additional information to enhance our understanding of the genetic and metabolic network of halophilic bacteria, but also accelerate the research on systematical design of engineering strategies for biotechnology applications.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [MAG/110M613]; Marmara University Research Fund [FEN-C-YLP-060911-0280]en_US
dc.description.sponsorshipThis research has been financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK) through Grant MAG/110M613 and by Marmara University Research Fund through Grant FEN-C-YLP-060911-0280.en_US
dc.language.isoengen_US
dc.publisherSpringer International Publishingen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectHalomonas Smyrnensisen_US
dc.subjectHalophilesen_US
dc.subjectGenomeen_US
dc.subjectNext-Generation sequencingen_US
dc.subjectLevanen_US
dc.titleGenomic analysis reveals the biotechnological and industrial potential of levan producing halophilic extremophile, Halomonas smyrnensis AAD6Ten_US
dc.typearticleen_US
dc.relation.ispartofSpringerPlusen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-0060-2859en_US
dc.identifier.volume4en_US
dc.relation.ecinfo:eu repo/grantAgreement/TUBITAK/SOBAG/MAG/110M613en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1186/s40064-015-1184-3en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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