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dc.contributor.authorÜstün, Ramazan
dc.contributor.authorOğuz, Elif Kaval
dc.contributor.authorDelilbaşi, Çağrı
dc.contributor.authorŞeker, Ayşe
dc.contributor.authorTaşpınar, Filiz
dc.contributor.authorÖncü, Mehmet Reşit
dc.contributor.authorOğuz, Ahmet Regaip
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:05Z
dc.date.issued2017en_US
dc.identifier.citationÜstün, R., Oğuz, E., K., Delilbaşi, Ç., Şeker, A., Taşpınar, F., Öncü, M. R. ... Oğuz, A. R. (2017). Neuromuscular degenerative effects of Ankaferd Blood Stopper((R)) in mouse sciatic nerve model. Somatosensory and Motor Research, 34(4), 248-257. https://dx.doi.org/10.1080/08990220.2017.1421160en_US
dc.identifier.issn0899-0220
dc.identifier.issn1369-1651
dc.identifier.urihttps://dx.doi.org/10.1080/08990220.2017.1421160
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3801
dc.descriptionWOS: 000424495800006en_US
dc.descriptionPubMed ID: 29334308en_US
dc.description.abstractPurpose: Ankaferd Blood Stopper((R)) (ABS), a licenced medicinal herbal extract, is commonly used as an effective topical haemostatic agent. This study is designed to investigate whether topical ABS application may cause peripheral nerve degeneration and neuromuscular dysfunction in a mouse sciatic nerve model.Methods: Twenty mice were randomly divided into two groups; an ABS treated experimental group and a saline-treated control group. Left sciatic nerves were treated with 0.3ml of ABS in the experimental group and 0.3ml of sterile saline in the control group for 5min. Peripheral nerve degeneration and neuromuscular dysfunction were evaluated by behavioural tests, electrophysiological analysis and weight ratio comparison of target muscles.Results: The motor function, assessed by the sciatic function index, was significantly impaired in ABS-treated animals as compared to the animals treated with saline. Motor coordination, evaluated with the rotarod test, was significantly decreased (-42%) in ABS-treated animals compared to the saline-treated animals. The degree of pain, assessed by the reaction latency to thermal stimuli (hot-plate test), was significantly prolonged (313%) in ABS-treated mice when compared to the saline-treated mice. ABS-treated mice showed a significant reduction in motor nerve conduction velocity (MNCV) (-52%) and the compound muscle action potential (CMAP) (-47%); however, it significantly prolonged onset latency (23%). The gastrocnemius muscles weight ratio of the ABS group was considerably lower than that of the control group.Conclusions: These findings demonstrate that ABS triggers peripheral nerve degeneration and functional impairment and, thus promotes a deterioration of sciatic nerves.en_US
dc.description.sponsorshipVan Yuzuncu Yil University Scientific Research Project Directorate of Turkey [1562]en_US
dc.description.sponsorshipThis work was supported by Van Yuzuncu Yil University Scientific Research Project Directorate of Turkey [grant number 1562].en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnakaferd Blood Stopperen_US
dc.subjectFunctional Impairmenten_US
dc.subjectPeripheral Nerve Degenerationen_US
dc.titleNeuromuscular degenerative effects of Ankaferd Blood Stopper((R)) in mouse sciatic nerve modelen_US
dc.typearticleen_US
dc.relation.journalSomatosensory and Motor Researchen_US
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Ağız, Diş ve Çene Cerrahisi Ana Bilim Dalıen_US
dc.authorid0000-0003-3347-1151en_US
dc.identifier.volume34en_US
dc.identifier.issue4en_US
dc.identifier.startpage248en_US
dc.identifier.endpage257en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1080/08990220.2017.1421160en_US


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