Comparison of central corneal thickness with ultrasound pachymetry, noncontact specular microscopy and spectral domain optical coherence tomography
MetadataShow full item record
CitationKaraman Erdur, S., Demirci, G., Dikkaya, F.,Kocabora, M. ve Özsütçü, M. (2018). Comparison of central corneal thickness with ultrasound pachymetry, noncontact specular microscopy and spectral domain optical coherence tomography. Seminars in Ophthalmology, 33(6), 782-787. https://dx.doi.org/10.1080/08820538.2018.1448091
Background: To determine the agreement of central corneal thickness (CCT) measurements taken with ultrasonic pachymetry (USP), spectral domain optical coherence tomography (SD-OCT) and noncontact specular microscopy (NSM). Methods: A prospective, observational, cross-sectional study was performed in the outpatient ophthalmology clinic. CCT was measured in a total of 147 eyes of 147 consecutive healthy patients with USP, NSM, and SD-OCT. Same examiner performed all examinations. Bland-Altman plots were used to evaluate the agreement between instruments. Results: The average CCT values obtained by USP, NSM, and SD-OCT were 555 +/- 37 mu m, 554 +/- 34 mu m, and 546 +/- 34 mu m, respectively. There was a strong correlation between instruments: USP with SD-OCT (r = 0.937, p <0.01), USP with NSM (r = 0.943, p <0.01) SD-OCT with NSM (r = 0.975, p <0.01) for CCT. The mean differences (lower/upper limit of agreement) for CCT measurements were -10 +/- 12.9 pm (15.28/-35.28) between SD-OCT and USP-8.1 +/- 7.7 pm (7/-23.2) between SD-OCT and NSM, and 1.8 +/- 12.3 pm (25.9/-22.3) between USP and NSM. Conclusions: USP and NSM were found to have comparable CCT measurements and these two methods can be used correspondingly. However, CCT measurements by SD-OCT were lower when compared to other methods.