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dc.contributor.authorGünbey, Hediye Pınar
dc.contributor.authorErcan, Karabekir
dc.contributor.authorFındıkoğlu, Ayşe Serap
dc.contributor.authorBulut, Haci Taner
dc.contributor.authorKaraoğlanoğlu, Mustafa
dc.contributor.authorArslan, Halil
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:01Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:01Z
dc.date.issued2014en_US
dc.identifier.citationGünbey, H. P., Ercan, K., Fındıkoğlu, A. S., Bulut, H. T., Karaoğlanoğlu, M. ve Arslan, H. (2014). The limbic degradation of aging brain: A quantitative analysis with diffusion tensor imaging. The Scientific World Journal, 2014. https://dx.doi.org/10.1155/2014/196513en_US
dc.identifier.issn1537-744X
dc.identifier.urihttps://dx.doi.org/10.1155/2014/196513
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3785
dc.descriptionWOS: 000335020000001en_US
dc.descriptionPubMed ID: 24977184en_US
dc.description.abstractIntroduction. The limbic system primarily responsible for our emotional life and memories is known to undergo degradation with aging and diffusion tensor imaging (DTI) is capable of revealing thewhite matter integrity. Theaimof this study is to investigate agerelated changes of quantitative diffusivity parameters and fiber characteristics on limbic system in healthy volunteers. Methods. 31 healthy subjects aged 25-70 years were examined at 1,5 TMR. Quantitative fiber tracking was performed of fornix, cingulum, and the parahippocampal gyrus. The fractional anisotropy (FA) and apparent diffusion coefficient (ADC) measurements of bilateral hippocampus, amygdala, fornix, cingulum, and parahippocampal gyrus were obtained as related components. Results. The FA values of left hippocampus, bilateral parahippocampal gyrus, and fornix showed negative correlations with aging. The ADC values of right amygdala and left cingulum interestingly showed negative relation and the left hippocampus represented positive relation with age. The cingulum showed no correlation. The significant relative changes per decade of age were found in the cingulum and parahippocampal gyrus FA measurements. Conclusion. Our approach shows that aging affects hippocampus, parahippocampus, and fornix significantly but not cingulum. These findings reveal age-related changes of limbic system in normal population that may contribute to future DTI studies.en_US
dc.language.isoengen_US
dc.publisherHindawi Publishing Corporationen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 Unporteden_US
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/en_US
dc.subjectDiffusion Tensor Imaging (DTI)en_US
dc.subjectDegradation With Agingen_US
dc.subjectLimbicen_US
dc.titleThe limbic degradation of aging brain: A quantitative analysis with diffusion tensor imagingen_US
dc.typearticleen_US
dc.relation.ispartofThe Scientific World Journalen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Ana Bilim Dalıen_US
dc.identifier.volume2014en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1155/2014/196513en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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