Show simple item record

dc.contributor.authorBalkan, İlker İnanç
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorDurdu, Bülent
dc.contributor.authorBatırel, Ayşe
dc.contributor.authorHakyemez, İsmail Necati
dc.contributor.authorÇetin, Birsen
dc.contributor.authorKarabay, Oğuz
dc.contributor.authorGönen, İbak
dc.contributor.authorÖzkan, Ahmet Selim
dc.contributor.authorUzun, Sami
dc.contributor.authorDemirkol, Muhammed Emin
dc.contributor.authorAkbaş, Sedat
dc.contributor.authorKaçmaz, Asiye Bahar
dc.contributor.authorAras, Sükrü
dc.contributor.authorMert, Ali
dc.contributor.authorTabak, Fehmi
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:58Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:58Z
dc.date.issued2014en_US
dc.identifier.citationBalkan, İ. İ., Doğan, M., Durdu, B., Batırel, A., Hakyemez, İ. N., Çetin, B. ... Tabak, F. (2014). Colistin nephrotoxicity increases with age. Scandinavian Journal of Infectious Diseases, 46(10), 678-685. https://dx.doi.org/10.3109/00365548.2014.926021en_US
dc.identifier.issn0036-5548
dc.identifier.issn1651-1980
dc.identifier.urihttps://dx.doi.org/10.3109/00365548.2014.926021
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3776
dc.descriptionWOS: 000342202800002en_US
dc.descriptionPubMed ID: 25073536en_US
dc.description.abstractBackground: Colistin (COL) has become the backbone of the treatment of infections due to extensively drug-resistant (XDR) Gram-negative bacteria. The most common restriction to its use is acute kidney injury (AKI). Methods: We conducted a retrospective cohort study to evaluate risk factors for new-onset AKI in patients receiving COL. The cohort consisted of 198 adults admitted to 9 referral hospitals between January 2010 and October 2012 and treated with intravenous COL for >= 72 h. Patients with no pre-existing kidney dysfunction were compared in terms of risk factors and outcomes of AKI graded according to the RIFLE criteria. Logistic regression analysis was used to identify associated risk factors. Results: A total of 198 patients met the inclusion criteria, of whom 167 had no pre-existing kidney dysfunction; the mean patient age was 58.77 (+/- 18.98) y. Bloodstream infections (34.8%) and ventilator-associated pneumonia (32.3%) were the 2 most common indications for COL use. New-onset AKI developed in 46.1% of the patients, graded as risk (10%), injury (15%), and failure (21%). Patients with high Charlson co-morbidity index (CCI) scores (p = 0.001) and comparatively low initial glomerular filtration rate (GFR) estimations (p < 0.001) were more likely to develop AKI, but older age (p = 0.001; odds ratio 5.199, 95% confidence interval 2.684-10.072) was the major predictor in the multivariate analysis. In-hospital recovery from AKI occurred in 58.1%, within a median of 7 days. Conclusions: COL-induced nephrotoxicity occurred significantly more often in patients older than 60 y of age and was related to low initial GFR estimations and high CCI scores, which were basically determined by age.en_US
dc.language.isoengen_US
dc.publisherInforma Healthcareen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectColistinen_US
dc.subjectNephrotoxicityen_US
dc.subjectAgeen_US
dc.titleColistin nephrotoxicity increases with ageen_US
dc.typearticleen_US
dc.relation.ispartofScandinavian Journal of Infectious Diseasesen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-8945-2385en_US
dc.identifier.volume46en_US
dc.identifier.issue10en_US
dc.identifier.startpage678en_US
dc.identifier.endpage685en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3109/00365548.2014.926021en_US
dc.identifier.wosqualityQ3en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record