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New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents

dc.contributor.authorDemirayak, Şeref
dc.contributor.authorYurttaş, Leyla
dc.contributor.authorGündoğdu-Karaburun, Nalan
dc.contributor.authorKaraburun, Ahmet Çagrı
dc.contributor.authorKayagil, İsmail
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:58Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:58Z
dc.date.issued2017en_US
dc.identifier.citationDemirayak, Ş., Yurttaş, L., Gündoğdu-Karaburun, N., Karaburun, A. Ç. ve Kayagil, İ. (2017). New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents. Saudi Pharmaceutical Journal, 25(7), 1063-1072. https://dx.doi.org/10.1016/j.jsps.2017.04.040en_US
dc.identifier.issn1319-0164
dc.identifier.issn2213-7475
dc.identifier.urihttps://dx.doi.org/10.1016/j.jsps.2017.04.040
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3775
dc.descriptionWOS: 000414346300017en_US
dc.descriptionPubMed ID: 29158716en_US
dc.description.abstractThe synthesis of 3-[3/4-(2-aryl-2-oxoethoxy) arylidene] chroman/thiochroman-4-one derivatives (1-34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis reactions using phenol/thiophenol derivatives as starting materials. For anticancer activity evaluation, all compounds were offered to National Cancer Institute (NCI), USA and selected ones were tested against sixty human tumor cell lines derived from nine neoplastic diseases. The activity results were evaluated according to the drug screening protocol of the institute. Compounds containing thiochromanone skeleton exhibited higher anticancer activity.en_US
dc.description.sponsorshipAnadolu University, Turkey (BAP) [050301]en_US
dc.description.sponsorshipThis work was supported by Anadolu University, Turkey (BAP Project No: 050301). The authors present their thanks to NCI (USA) and Anadolu University BIBAM (Turkey) for anticancer test results and NMR spectra, respectively.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Bven_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectChromanoneen_US
dc.subjectThiochromanoneen_US
dc.subjectBenzopyranoneen_US
dc.subjectBenzothiopyranoneen_US
dc.subjectFlavoneen_US
dc.subjectAlpha, Beta-Unsaturated Carbonylen_US
dc.subjectAnticancer Activityen_US
dc.titleNew chroman-4-one/thiochroman-4-one derivatives as potential anticancer agentsen_US
dc.typearticleen_US
dc.relation.ispartofSaudi Pharmaceutical Journalen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.authorid0000-0002-0841-1299en_US
dc.identifier.volume25en_US
dc.identifier.issue7en_US
dc.identifier.startpage1063en_US
dc.identifier.endpage1072en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jsps.2017.04.040en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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