Positioning Europe for the epitranscriptomics challenge
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info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-nd/4.0/Tarih
2018Yazar
Jantsch, Michael F.Quattrone, Alessandro
O'Connell, Mary
Helm, Mark
Frye, Michaela
Macias-Gonzales, Manuel
Ohman, Marie
Ameres, Stefan
Willems, Luc
Fuks, Francois
Oulas, Anastasis
Vanacova, Stepanka
Nielsen, Henrik
Bousquet-Antonelli, Cecile
Motorin, Yuri
Roignant, Jean-Yves
Balatsos, Nikolaos
Dinnyes, Andras
Baranov, Pavel
Kelly, Vincent
Lamm, Ayelet
Rechavi, Gideon
Pelizzola, Mattia
Liepins, Janis
Kholodnyuk, Irina Holodnuka
Zammit, Vanessa
Ayers, Duncan
Drablos, Finn
Dahl, John Arne
Bujnicki, Janusz
Jeronimo, Carmen
Almeida, Raquel
Neagu, Monica
Costache, Marieta
Bankovic, Jasna
Banovic, Bojana
Kyselovic, Jan
Valor, Luis Miguel
Selbert, Stefan
Pir, Pinar
Demircan, Turan
Cowling, Victoria
Schaefer, Matthias
Rossmanith, Walter
Lafontaine, Denis
David, Alexandre
Carre, Clement
Lyko, Frank
Schaffrath, Raffael
Schwartz, Schraga
Verdel, Andre
Klungland, Arne
Purta, Elzbieta
Timotijevic, Gordana
Cardona, Fernando
Davalos, Alberto
Ballana, Ester
O'Carroll, Donal
Ule, Jernej
Fray, Rupert
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Jantsch, M. F., Quattrone, A., O'Connell, M., Helm, M., Helm, M., Macias-Gonzales, M. ... Fray, R. (2018). Positioning Europe for the epitranscriptomics challenge. RNA Biology, 15(6), 829–831. https://dx.doi.org/10.1080/15476286.2018.1460996Özet
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the similar to 150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.