dc.contributor.author | Üstündağ, Ünsal Veli | |
dc.contributor.author | Şahin, Sadık | |
dc.contributor.author | Ak, Koray | |
dc.contributor.author | Keskin, İlknur | |
dc.contributor.author | Emekli Alturfan, Ebru | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:02:51Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:02:51Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Üstündağ, Ü. V., Şahin, S., Ak, K., Keskin, İ. ve Emekli Alturfan, E. (2015). The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. Reproductive Biology, 15(3), 139-145. https://dx.doi.org/10.1016/j.repbio.2015.07.002 | en_US |
dc.identifier.issn | 1642-431X | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.repbio.2015.07.002 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3748 | |
dc.description | WOS: 000362463000002 | en_US |
dc.description | PubMed ID: 26370456 | en_US |
dc.description.abstract | In the present study, the effects of tacrolimus on the activity and expression of tissue factor (TF) were investigated in the ovarian ischemia-reperfusion induced injury in rats. Twenty-eight female rats (8-12 weeks, 300-350 g) were divided into four groups: control, ischemia-reperfusion (IR), tacrolimus treated before ischemia (TBI), and tacrolimus treated before reperfusion (TBR) groups (n = 7/per group). TF activity was measured using Quick's method, whereas TF expression was examined immunohistochemically. TF activity was significantly higher in all treated groups compared with the control group. Strong ovarian TF expression was demonstrated in the IR and TBR groups. Moreover, tacrolimus decreased TF activity in the TBI group compared with the IR group. The decreased activity of TF in the ovarian IR model may prevent IR-related inflammation during transplant procedure. (C) 2015 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. | en_US |
dc.description.sponsorship | Commission of Scientific Investigations Projects of Marmara University (Turkey) [SAG-C-YLP-120613-0240] | en_US |
dc.description.sponsorship | This study was financially supported by Grant Project No: SAG-C-YLP-120613-0240 from the Commission of Scientific Investigations Projects of Marmara University (Turkey). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Institute of Animal Reproduction and Food Research | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Tacrolimus | en_US |
dc.subject | Tissue Factor | en_US |
dc.subject | Ovary | en_US |
dc.subject | Ischemia Reperfusion | en_US |
dc.title | The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Reproductive Biology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-7059-1884 | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 139 | en_US |
dc.identifier.endpage | 145 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.repbio.2015.07.002 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q1 | en_US |