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dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorŞahin, Sadık
dc.contributor.authorAk, Koray
dc.contributor.authorKeskin, İlknur
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:51Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:51Z
dc.date.issued2015en_US
dc.identifier.citationÜstündağ, Ü. V., Şahin, S., Ak, K., Keskin, İ. ve Emekli Alturfan, E. (2015). The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. Reproductive Biology, 15(3), 139-145. https://dx.doi.org/10.1016/j.repbio.2015.07.002en_US
dc.identifier.issn1642-431X
dc.identifier.urihttps://dx.doi.org/10.1016/j.repbio.2015.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3748
dc.descriptionWOS: 000362463000002en_US
dc.descriptionPubMed ID: 26370456en_US
dc.description.abstractIn the present study, the effects of tacrolimus on the activity and expression of tissue factor (TF) were investigated in the ovarian ischemia-reperfusion induced injury in rats. Twenty-eight female rats (8-12 weeks, 300-350 g) were divided into four groups: control, ischemia-reperfusion (IR), tacrolimus treated before ischemia (TBI), and tacrolimus treated before reperfusion (TBR) groups (n = 7/per group). TF activity was measured using Quick's method, whereas TF expression was examined immunohistochemically. TF activity was significantly higher in all treated groups compared with the control group. Strong ovarian TF expression was demonstrated in the IR and TBR groups. Moreover, tacrolimus decreased TF activity in the TBI group compared with the IR group. The decreased activity of TF in the ovarian IR model may prevent IR-related inflammation during transplant procedure. (C) 2015 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn.en_US
dc.description.sponsorshipCommission of Scientific Investigations Projects of Marmara University (Turkey) [SAG-C-YLP-120613-0240]en_US
dc.description.sponsorshipThis study was financially supported by Grant Project No: SAG-C-YLP-120613-0240 from the Commission of Scientific Investigations Projects of Marmara University (Turkey).en_US
dc.language.isoengen_US
dc.publisherInstitute of Animal Reproduction and Food Researchen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectTacrolimusen_US
dc.subjectTissue Factoren_US
dc.subjectOvaryen_US
dc.subjectIschemia Reperfusionen_US
dc.titleThe effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injuryen_US
dc.typearticleen_US
dc.relation.ispartofReproductive Biologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-7059-1884en_US
dc.identifier.volume15en_US
dc.identifier.issue3en_US
dc.identifier.startpage139en_US
dc.identifier.endpage145en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.repbio.2015.07.002en_US
dc.identifier.wosqualityQ4en_US
dc.identifier.scopusqualityQ1en_US


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