dc.contributor.author | Avcı, Nilüfer | |
dc.contributor.author | Türe, Mehmet | |
dc.contributor.author | Deligönül, Adem | |
dc.contributor.author | Çubukçu, Erdem | |
dc.contributor.author | Ölmez, Ömer Fatih | |
dc.contributor.author | Şahintürk, Serdar | |
dc.contributor.author | Topak, Ali | |
dc.contributor.author | Kurt, Ender | |
dc.contributor.author | Evrensel, Türkan | |
dc.contributor.author | Şahin, Ahmet Bilgehan | |
dc.contributor.author | Yakut, Tahsin | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:02:22Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:02:22Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Avcı, N., Türe, M., Deligönül, A., Çubukçu, E., Ölmez, Ö. F., Şahintürk, S. ... Yakut, T. (2015). Association and prognostic significance of the functional-1562C/T polymorphism in the promoter region of MMP-9 in Turkish patients with gastric cancer. Pathology & Oncology Reserach, 21(4), 1243-1247. https://dx.doi.org/10.1007/s12253-015-9950-7 | en_US |
dc.identifier.issn | 1219-4956 | |
dc.identifier.issn | 1532-2807 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s12253-015-9950-7 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3630 | |
dc.description | WOS: 000360385400050 | en_US |
dc.description | PubMed ID: 26156886 | en_US |
dc.description.abstract | Matrix metalloproteinases (MMPs) are a group of zinc-dependent peptidases that participate in matrix turnover in solid malignancies. The aim of this study was twofold. First, we sought to investigate under a case-control design the association between the functional -1562C/T polymorphism in the promoter region of MMP-9 and gastric cancer (GC) in a Turkish sample. Second, we examined its prognostic significance in GC patients. A total of 144 subjects were enrolled in the case-control study (79 GC cases and 65 controls). Overall survival (OS) and progression-free survival (PFS) served as the main outcome measures in the longitudinal study. The MMP-9 -1562C/T polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism method. The odds ratio (OR) of GC for the CC genotype relative to the CT+TT genotypes was not significant (OR = 0.89, 95 % confidence interval [CI] = 0.44-1.82, P = 0.75). These results did not change after allowance for age and sex in multivariable regression analysis (OR = 0.81, 95 % CI = 0.40-1.94, P = 0.84). When the MMP-9 -1562C/T polymorphism was analyzed among GC patients in relation to OS and PFS, we found no significant differences between subjects with the CC and CT+TT genotypes. In conclusion, the results of our study did not point toward a major role of the MMP-9 -1562C/T polymorphism in the pathogenesis and clinical course of GC in Turkish subjects. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Gastric Cancer | en_US |
dc.subject | Matrix Metalloproteinases | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Association Study | en_US |
dc.subject | Prognosis | en_US |
dc.title | Association and prognostic significance of the functional-1562C/T polymorphism in the promoter region of MMP-9 in Turkish patients with gastric cancer | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Pathology & Oncology Reserach | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 21 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 1243 | en_US |
dc.identifier.endpage | 1247 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1007/s12253-015-9950-7 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q2 | en_US |