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dc.contributor.authorAvcı, Nilüfer
dc.contributor.authorTüre, Mehmet
dc.contributor.authorDeligönül, Adem
dc.contributor.authorÇubukçu, Erdem
dc.contributor.authorÖlmez, Ömer Fatih
dc.contributor.authorŞahintürk, Serdar
dc.contributor.authorTopak, Ali
dc.contributor.authorKurt, Ender
dc.contributor.authorEvrensel, Türkan
dc.contributor.authorŞahin, Ahmet Bilgehan
dc.contributor.authorYakut, Tahsin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:22Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:22Z
dc.date.issued2015en_US
dc.identifier.citationAvcı, N., Türe, M., Deligönül, A., Çubukçu, E., Ölmez, Ö. F., Şahintürk, S. ... Yakut, T. (2015). Association and prognostic significance of the functional-1562C/T polymorphism in the promoter region of MMP-9 in Turkish patients with gastric cancer. Pathology & Oncology Reserach, 21(4), 1243-1247. https://dx.doi.org/10.1007/s12253-015-9950-7en_US
dc.identifier.issn1219-4956
dc.identifier.issn1532-2807
dc.identifier.urihttps://dx.doi.org/10.1007/s12253-015-9950-7
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3630
dc.descriptionWOS: 000360385400050en_US
dc.descriptionPubMed ID: 26156886en_US
dc.description.abstractMatrix metalloproteinases (MMPs) are a group of zinc-dependent peptidases that participate in matrix turnover in solid malignancies. The aim of this study was twofold. First, we sought to investigate under a case-control design the association between the functional -1562C/T polymorphism in the promoter region of MMP-9 and gastric cancer (GC) in a Turkish sample. Second, we examined its prognostic significance in GC patients. A total of 144 subjects were enrolled in the case-control study (79 GC cases and 65 controls). Overall survival (OS) and progression-free survival (PFS) served as the main outcome measures in the longitudinal study. The MMP-9 -1562C/T polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism method. The odds ratio (OR) of GC for the CC genotype relative to the CT+TT genotypes was not significant (OR = 0.89, 95 % confidence interval [CI] = 0.44-1.82, P = 0.75). These results did not change after allowance for age and sex in multivariable regression analysis (OR = 0.81, 95 % CI = 0.40-1.94, P = 0.84). When the MMP-9 -1562C/T polymorphism was analyzed among GC patients in relation to OS and PFS, we found no significant differences between subjects with the CC and CT+TT genotypes. In conclusion, the results of our study did not point toward a major role of the MMP-9 -1562C/T polymorphism in the pathogenesis and clinical course of GC in Turkish subjects.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectGastric Canceren_US
dc.subjectMatrix Metalloproteinasesen_US
dc.subjectPolymorphismen_US
dc.subjectAssociation Studyen_US
dc.subjectPrognosisen_US
dc.titleAssociation and prognostic significance of the functional-1562C/T polymorphism in the promoter region of MMP-9 in Turkish patients with gastric canceren_US
dc.typearticleen_US
dc.relation.ispartofPathology & Oncology Reserachen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.identifier.volume21en_US
dc.identifier.issue4en_US
dc.identifier.startpage1243en_US
dc.identifier.endpage1247en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s12253-015-9950-7en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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