dc.contributor.author | Karaca, Oğuz | |
dc.contributor.author | Güneş, Hacı Murat | |
dc.contributor.author | Omaygenç, Mehmet Onur | |
dc.contributor.author | Çakal, Beytullah | |
dc.contributor.author | Çakal Deniz, Sinem | |
dc.contributor.author | Demir, Gültekin Günhan | |
dc.contributor.author | Kızılırmak, Filiz | |
dc.contributor.author | Gökdeniz, Tayyar | |
dc.contributor.author | Barutçu, İrfan | |
dc.contributor.author | Boztosun, Bilal | |
dc.contributor.author | Kılıçaslan, Fethi | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:02:19Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:02:19Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Karaca, O., Güneş, H. M., Omaygenç, M. O., Çakal, B., Çakal Deniz, S., Demir, G. G. ... Kılıçaslan, F. (2016). Predicting ventricular arrhythmias in cardiac resynchronization therapy: The impact of persistent electrical dyssynchrony. Pace-Pacing And Clinical Electrophysiology, 39(9), 969-977. https://dx.doi.org/10.1111/pace.12908 | en_US |
dc.identifier.issn | 0147-8389 | |
dc.identifier.issn | 1540-8159 | |
dc.identifier.uri | https://dx.doi.org/10.1111/pace.12908 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3615 | |
dc.description | WOS: 000383572900008 | en_US |
dc.description | PubMed ID: 27333978 | en_US |
dc.description.abstract | BackgroundAlthough response to cardiac resynchronization therapy (CRT) has been conventionally assessed with left ventricular volume reduction, ventricular arrhythmias (ventricular tachycardia/ventricular fibrillation [VT/VF]) are of critical importance associated with unfavorable outcomes even in the superresponders to therapy. We evaluated the predictors of VT/VF and the association of residual dyssynchrony during follow-up. MethodsNinety-five patients receiving CRT were followed-up for 9 3 months. Post-CRT dyssynchrony was defined as a prolonged QRS duration (QRSd) for persistent electrical dyssynchrony (ED), and a Yu index 33 ms for persistent mechanical dyssynchrony. The first VT/VF episode, including nonsustained VT detected on device interrogation and/or appropriate antitachycardia pacing or shock for VT/VF, were the end points of the study. ResultsForty-five patients who reached the study end points had significantly lower mean QRS (baseline QRSd - post-CRT QRSd) values than those without VT/VF (-20.8 +/- 28.9 ms vs -6.6 +/- 30.7 ms, P = 0.022). Both the baseline and post-CRT QRSds, along with the Yu index values, were not different in two groups. Patients with VT/VF were statistically more likely to have persistent ED (38% vs 9%, P = 0.021). Kaplan-Meier curves showed that a negative QRS was associated with a higher incidence of VT/VF during follow-up (P = 0.016). A multivariate Cox model revealed that QRS prolongation was an independent predictor of VT/VF after CRT (P = 0.029). ConclusionsA negative QRS, also called persistent ED, is associated with VT/VF. Narrowest possible QRSd might be a reliable goal of both implantation and optimization of devices to reduce arrhythmic events after CRT. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Cardiac Resynchronization Therapy | en_US |
dc.subject | QRS Duration | en_US |
dc.subject | Ventricular Arrhythmia | en_US |
dc.subject | Electrical Dyssynchrony | en_US |
dc.subject | Mechanical Dyssynchrony | en_US |
dc.title | Predicting ventricular arrhythmias in cardiac resynchronization therapy: The impact of persistent electrical dyssynchrony | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Pace-Pacing And Clinical Electrophysiology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-4281-0867 | en_US |
dc.authorid | 0000-0003-2995-8792 | en_US |
dc.authorid | 0000-0003-0230-6575 | en_US |
dc.authorid | 0000-0003-2714-4584 | en_US |
dc.authorid | 0000-0001-9975-5507 | en_US |
dc.authorid | 0000-0003-1919-3183 | en_US |
dc.identifier.volume | 39 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 969 | en_US |
dc.identifier.endpage | 977 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1111/pace.12908 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q2 | en_US |