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dc.contributor.authorSadıkoğlu Bekçi, Tuğba
dc.contributor.authorNalbantgil, Didem
dc.contributor.authorÜlkür, Feyza
dc.contributor.authorUlaş, Nilüfer
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:16Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:16Z
dc.date.issued2016en_US
dc.identifier.citationSadıkoğlu Bekçi, T., Nalbantgil, D., Ülkür, F. ve Ulaş, N. (2016). Effect of hyaluronic acid on bone formation in the expanded interpremaxillary suture in rats. Orthodontics & Craniofacial Research, 19(3), 154-161. https://dx.doi.org/10.1111/ocr.12123en_US
dc.identifier.issn1601-6335
dc.identifier.issn1601-6343
dc.identifier.urihttps://dx.doi.org/10.1111/ocr.12123
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3600
dc.descriptionWOS: 000379974400004en_US
dc.descriptionPubMed ID: 27132627en_US
dc.description.abstractStructured Abstract ObjectiveTo evaluate the histomorphometric effects of different molecular weight hyaluronic acid on bone formation in rats after expansion of the interpremaxillary suture. Material and MethodsTwenty-four male Sprague Dawley rats were divided into three groups. Each group was subjected to expansion for 5 days and retention for 10 days. Group 1 received 50 l of high molecular weight hyaluronic acid (HMWHA), group 2 received 50 l of low molecular weight hyaluronic acid (LMWHA), and the control group received same amount of saline solution to the interpremaxillary suture. Ten days after injection, the rats were killed and their maxillas dissected. For the histomorphometric evaluation, blocks were serially sectioned at 10-m intervals. Sections were stained with hematoxylin-eosin (HE) and evaluated with image analysis software. Bone area (m(2)) (BA), bone perimeter of suture borders (m) (BP), and ratio of osteoblast cells and capillary cells to BA and BP parameters were evaluated. ResultsHMWHA showed a statistically higher ratio of osteoblast and capillary cell scores compared with the LMWHA and control groups (p < 0.05). There were no statistically significant differences in between LMWHA and control groups (p > 0.05). ConclusionsLocal injection of HMWHA in the interpremaxillary suture after rapid maxillary expansion stimulated new bone formation, which may shorten the retention period and may reduce the risk of relapse. LMWHA has no effect on bone formation in interpremaxillary suture.en_US
dc.description.sponsorshipMedipol University Department of Histologyen_US
dc.description.sponsorshipHistomorphometric and Histopathological evaluation was supported by Medipol University Department of Histology. We appreciate Assist. Prof. Cigdem Kaspar's for help on statistical analysis.en_US
dc.language.isoengen_US
dc.publisherWiley Blackwellen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectHistomorphometryen_US
dc.subjectHyaluronic Aciden_US
dc.subjectMaxillary Expansionen_US
dc.subjectOrthodonticsen_US
dc.subjectRaten_US
dc.titleEffect of hyaluronic acid on bone formation in the expanded interpremaxillary suture in ratsen_US
dc.typearticleen_US
dc.relation.journalOrthodontics & Craniofacial Researchen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.identifier.volume19en_US
dc.identifier.issue3en_US
dc.identifier.startpage154en_US
dc.identifier.endpage161en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/ocr.12123en_US


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