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Role of urotensin-2 in 5-fluorouracil-related arterial vasoconstriction in cancer patients

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info:eu-repo/semantics/openAccess

Date

2018

Author

Şeker, Mesut
İsen, Hayati Can
Çevirme, Nidal
Aydın, Sinem
Bilici, Ahmet
Bulut, Huri
Yasin, Ayşe İrem
Çoban, Ezgi
Demir, Tarık
Aliyev, Altay
Koçyiğit, Abdurrahim
Türk, Hacı Mehmet

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Şeker, M., İsen, H. C., Çevirme, N., Aydın, S., Bilici, A., Bulut, H. ... Türk, H. M. (2018). Role of urotensin-2 in 5-fluorouracil-related arterial vasoconstriction in cancer patients. Journal of Oncology Research and Treatment, 41(9), 545-549. https://dx.doi.org/10.1159/000490120

Abstract

Background: The aim of this study was to identify the possible relationship of 5-fluorouracil (5-FU)-related arterial vasoconstriction with urotensin-2 (UT-2), which has a high potential as an endogenic vasoconstrictor. Methods: We assigned the patients to 1 of 3 groups. Patients in group 1 received a bolus of 5-FU, those in group2a continuous infusion (CI) of 5-FU, and those in group 3 no 5-FU, which was also a control group. Pre- and post-treatment UT-2 levels and brachial arterial diameters were measured and recorded in all patients. Results: 132 patients were included in the study. Pre-and post-treatment brachial artery diameters were similar in all groups: in group 1 (3.28 +/- 0.52 vs. 3.25 +/- 0.44 mm, p = 0.740), in group 2 (3.57 +/- 0.47 vs. 3.46 +/- 0.45 mm, p = 0.441) and in the control group (3.51 +/- 0.52 vs. 3.25 +/- 0.44 mm, p = 0.818). Pre-and post-treatment UT-2 levels were significantly different in each group: in group 1 (39.5 +/- 30.9 vs. 56.7 +/- 27.1 ng/ml, p = 0.0001), in group 2 (37.7 +/- 33.7 vs. 62.5 +/- 37.7 ng/ml, p = 0.0001) and in the control group (52.9 +/- 40.2 vs. 60.8 +/- 40.7 ng/ml, p = 0.006). Conclusion: Our findings suggest that UT-2 has a high potential as a vasoconstrictor agent in our bodies and its level increases through a bolus or CI 5-FU. Increased UT-2 levels are likely to play a role in 5-FU-related cardiac toxicity pathogenesis.

WoS Q Kategorisi

Q4

xmlui.dri2xhtml.METS-1.0.item-scopusquality

Q3

Source

Oncology Research and Treatment

Volume

41

Issue

9

URI

https://dx.doi.org/10.1159/000490120
https://hdl.handle.net/20.500.12511/3589

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  • Makale Koleksiyonu [3454]
  • PubMed İndeksli Yayınlar Koleksiyonu [3769]
  • Scopus İndeksli Yayınlar Koleksiyonu [5815]
  • WoS İndeksli Yayınlar Koleksiyonu [5982]



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