Serum and aqueous concentrations of inflammatory markers in diabetic macular edema
Telli, Mehmet Erdem
Erdur Karaman, Sevil
Özbilen, Kemal Turgay
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KünyeKocabora, S., Telli, M. E., Fazıl, K., Erdur Karaman, S., Özsütçü, M., Çekiç, O. ... Özbilen, K. T. (2016). Serum and aqueous concentrations of inflammatory markers in diabetic macular edema. Ocular Immunology And Inflammation, 24(5), 549-554. https://dx.doi.org/10.3109/09273948.2015.1034804
Purpose: To investigate the relationship between the serum and aqueous levels of inflammatory markers and diabetic macular edema (DME).Methods: The study included four patient groups: the healthy control group (n=23 eyes); the diabetic control group (n=22 eyes); the groups with and without DME (n=20 eyes and n=22 eyes, respectively). The patients were evaluated based on their serum levels of HbA(1c), C-reactive protein (CRP) and serum and aqueous levels of tumor necrosis factor-alpha (TNF-).Results: Statistically significant differences were present for the serum CRP levels and for the aqueous TNF- levels between the healthy control group and the group with DME (p=0.004 and p=0.03, respectively); for the serum TNF- levels between the healthy control group and the groups without and with DME (p=0.009 and p=0.001, respectively).Conclusions: Increased serum levels of CRP and serum and aqueous levels of TNF- in DME suggest that inflammation is involved in the pathogenesis of DME.