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dc.contributor.authorShahbazi, Reza
dc.contributor.authorÖzçicek, İlyas
dc.contributor.authorÖztürk, Gürkan
dc.contributor.authorUlubayram, Kezban
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:53Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:53Z
dc.date.issued2017en_US
dc.identifier.citationShahbazi, R., Özçicek, İ., Öztürk, G. ve Ulubayram, K. (2017). Functionalized gold nanoparticles manifested as potent carriers for nucleolar targeting. Nanotechnology, 28(2). https://dx.doi.org/10.1088/1361-6528/28/2/025103en_Us
dc.identifier.issn0957-4484
dc.identifier.issn1361-6528
dc.identifier.urihttps://dx.doi.org/10.1088/1361-6528/28/2/025103
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3477
dc.descriptionWOS: 000390560900001en_US
dc.descriptionPubMed ID: 27924783en_US
dc.description.abstractIt is generally known that gold nanoparticles are localised in the cytoplasm and, if synthesised in small sizes or functionalized with specific proteins, they enter the cell nucleus. However, there is no report emphasising the importance of surface functionalization in their accumulation in the nucleolus. Here, for the first time in the. literature, it is proposed that functionalization of gold nanoparticles with a thin layer of polyethyleneimine (PEI) spearheads them to the nucleolus of hard-to-transfect post-mitotic dorsal root ganglion neurones in a size-independent manner. As a potential for theranostic applications, it was found that functionalization with a. thin layer of PEI affected the emission signal intensity of gold nanoparticles so that the. cellular biodistribution of nanoparticles was visualised. clearly under both confocal and two-photon microscopes.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [2215, 2211-C]en_US
dc.description.sponsorshipThe authors would like to thank Dr Steve Perrault for his valuable comments and consults for the study. This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) 2215 and 2211-C scholarship programs.en_US
dc.language.isoengen_US
dc.publisherIop Publishing Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNucleolusen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectTheranosticsen_US
dc.titleFunctionalized gold nanoparticles manifested as potent carriers for nucleolar targetingen_US
dc.typearticleen_US
dc.relation.ispartofNanotechnologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-0352-1947en_US
dc.identifier.volume28en_US
dc.identifier.issue2en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1088/1361-6528/28/2/025103en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ1en_US


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