dc.contributor.author | Kantarcıoğlu, Bülent | |
dc.contributor.author | Beköz, Hüseyin Saffet | |
dc.contributor.author | Duvarcı Öğret, Yeliz | |
dc.contributor.author | Çakır, Aslı | |
dc.contributor.author | Kıvanç, Demet | |
dc.contributor.author | Oğuz Savran, Fatma | |
dc.contributor.author | Sargın, Deniz | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:01:48Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:01:48Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Kantarcıoğlu, B., Beköz, H. S., Duvarcı Öğret, Y., Çakır, A., Kıvanç, D., Oğuz, F. S. ... Sargın, D. (2016). Isolated extramedullary cutaneous relapse despite concomitant severe graft-vs.-host disease and tissue chimerism analysis in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: A case report. Molecular and Clinical Oncology, 5(6), 745-749. https://dx.doi.org/10.3892/mco.2016.1052 | en_US |
dc.identifier.issn | 2049-9450 | |
dc.identifier.issn | 2049-9469 | |
dc.identifier.uri | https://dx.doi.org/10.3892/mco.2016.1052 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3452 | |
dc.description | WOS: 000453169800014 | en_US |
dc.description | PubMed ID: 28105353 | en_US |
dc.description.abstract | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment option for patients with acute lymphoblastic leukemia (ALL). The curative potential of allo-HSCT for ALL is, in part, due to the graft-vs.-leukemia (GVL) effect, in addition to the intensive conditioning chemo-radiotherapy. However, relapse remains the major cause of treatment failure following allo-HSCT for ALL. In the allo-HSCT setting, testing for genetic markers of hematopoietic chimerism has become a part of the routine diagnostic program. Routine chimerism analysis is usually performed in peripheral blood or bone marrow; in fact, little is known about the value of tissue chimerism in patients with extramedullary relapse (EMR) after the allo-HSCT setting. The present study reports on, a case of a patient with ALL who experienced isolated cutaneous EMR despite ongoing graft-vs.-host disease (GVHD), and the results of peripheral blood and skin tissue chimerism studies using multiplex polymerase chain reaction (PCR) of short tandem repeats (STR-PCR). The present case demonstrates that, although complete remission and/or chimerism may be achieved in the bone marrow, chimerism achieved at the tissue level, and the subsequent GVL effect, may be limited, despite concomitant severe GVHD following allo-HSCT. Our tissue chimerism analysis results provide a good example of how skin tissue may be a 'sanctuary' site for effector cells of GVL, despite active GVHD and complete hematopoetic chimerism. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Spandidos Publ Ltd. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Acute Lymphoblastic Leukemia | en_US |
dc.subject | Allogeneic Stem Cell Transplantation | en_US |
dc.subject | Extramedullary Relapse | en_US |
dc.subject | Tissue Chimerism | en_US |
dc.title | Isolated extramedullary cutaneous relapse despite concomitant severe graft-vs.-host disease and tissue chimerism analysis in a patient with acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation: A case report | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Molecular and Clinical Oncology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-3060-721X | en_US |
dc.authorid | 0000-0003-1237-8281 | en_US |
dc.authorid | 0000-0003-0128-6947 | en_US |
dc.authorid | 0000-0002-6018-8936 | en_US |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 745 | en_US |
dc.identifier.endpage | 749 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.3892/mco.2016.1052 | en_US |