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dc.contributor.authorYuluğ, Burak
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorKhanmammadov, Elmir
dc.contributor.authorArıcı Düz, Özge
dc.contributor.authorPolat, Burcu
dc.contributor.authorHanoğlu, Taha
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorKılıç, Ertuğrul
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:48Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:48Z
dc.date.issued2018en_US
dc.identifier.citationYuluǧ, B., Hanoǧlu, L., Khanmammadov, E., Arıcı Düz, Ö., Polat, B., Hanoğlu, T. ... Kılıç, E. (2018). Beyond the therapeutic effect of RTMS in Alzheimer’s disease: A possible neuroprotective role of hippocampal BDNF?: A minireview. Mini-Reviews in Medicinal Chemistry, 18(17), 1479-1485. https://dx.doi.org/10.2174/1389557517666170927162537en_US
dc.identifier.issn1389-5575
dc.identifier.issn1875-5607
dc.identifier.urihttps://dx.doi.org/10.2174/1389557517666170927162537
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3448
dc.descriptionWOS: 000444438600004en_US
dc.descriptionPubMed ID: 28971775en_US
dc.description.abstractRepetitive transcranial magnetic stimulation (rTMS) is a well known non-invasive brain stimulation procedure which is capable of inducing the expression of the hippocampal BDNF that has been already shown to exert significant neuroprotective and pro-cognitive effects in AD. However, it is nearly impossible directly to evaluate the BDNF expression in humans after rTMS application. Here we summarized the underlying mechanisms of the neuroprotective and procognitive effect of BDNF that can be induced through a region-specific rTMS approach. Additionally, we have also evaluated the role of Magnetic Resonance Spectroscopy in monitoring the BDNF response after rTMS application in Alzheimer's Disease. We have provided strong evidence that rTMS exerts significant neuroprotective and pro-cognitive effects through the expression of hippocampal BDNF. Furthermore, Magnetic Resonance Spectroscopy might play a critical role in monitoring the BDNF response after rTMS application in AD patients. Such a sophisticated approach might be able to enlighten us on the time-dependent cognitive and neuroprotective correlates of the rtMS application in AD patients.en_US
dc.language.isoengen_US
dc.publisherBentham Science Publishers B.V.en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRTMSen_US
dc.subjectBDNFen_US
dc.subjectMRSen_US
dc.subjectHippocampusen_US
dc.subjectNeuroprotectiveen_US
dc.subjectAD Patientsen_US
dc.titleBeyond the therapeutic effect of RTMS in Alzheimer’s disease: A possible neuroprotective role of hippocampal BDNF?: A minireviewen_US
dc.typereviewen_US
dc.relation.ispartofMini-Reviews in Medicinal Chemistryen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0002-9704-6173en_US
dc.authorid0000-0003-4292-5717en_US
dc.authorid0000-0003-0334-811Xen_US
dc.authorid0000-0001-7702-2441en_US
dc.authorid0000-0001-6494-8923en_US
dc.identifier.volume18en_US
dc.identifier.issue17en_US
dc.identifier.startpage1479en_US
dc.identifier.endpage1485en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.2174/1389557517666170927162537en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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