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dc.contributor.authorDuran, Murat
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:45Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:45Z
dc.date.issued2013en_US
dc.identifier.citationDuran, M. ve Demirayak, Ş. (2013). Synthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N-(thiazole-2-yl)acetamide derivatives and their anticancer activities. Medıcınal Chemistry Research, 22(9), 4110-4124. https://dx.doi.org/10.1007/s00044-012-0411-5en_US
dc.identifier.issn1054-2523
dc.identifier.urihttps://dx.doi.org/10.1007/s00044-012-0411-5
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3428
dc.descriptionWOS: 000322181300007en_US
dc.description.abstractIn this work, 2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N-(thiazol-2-yl) acetamide derivatives were synthesized by reacting 4,5-dimethyl-1-(phenylamino)-1H-imidazole-2(3H)-thione derivatives with some 2-chloro-N-(thiazol-2-yl)acetamide compounds. The structure of synthesized compounds was confirmed by IR, H-1 NMR, and mass spectra. Anticancer activities of the compounds selected by the National Cancer Institute were investigated by testing against a panel of 60 different human tumor cell lines derived from nine neoplastic cancer types. Compounds 7, 13, and 23 exhibited reasonable anticancer activity against the screened cancer types with relatively low GI(50) values. The compounds showed high activity against melanoma-type cell lines.en_US
dc.description.sponsorshipEskisehir Osmangazi Universityen_US
dc.description.sponsorshipThe authors would like to thank Eskisehir Osmangazi University for support and the National Cancer Institute (NCI), Bethesda, MD, USA, for in vitro screening of the compounds in human cancer cell lines.en_US
dc.language.isoengen_US
dc.publisherSpringer Birkhauseren_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectImidazoleen_US
dc.subjectThiazoleen_US
dc.subjectAnticanceren_US
dc.subjectMelanomaen_US
dc.subjectAcetamideen_US
dc.titleSynthesis of 2-[4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio]-N-(thiazole-2-yl)acetamide derivatives and their anticancer activitiesen_US
dc.typearticleen_US
dc.relation.journalMedıcınal Chemistry Researchen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.identifier.volume22en_US
dc.identifier.issue9en_US
dc.identifier.startpage4110en_US
dc.identifier.endpage4124en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s00044-012-0411-5en_US


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