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dc.contributor.authorYüksel, İsa Öner
dc.contributor.authorKöklü, Erkan
dc.contributor.authorArslan, Şakir
dc.contributor.authorÇağırcı, Göksel
dc.contributor.authorGöksü Özaydın, Eylem
dc.contributor.authorKoç, Pınar
dc.contributor.authorÇay, Serkan
dc.contributor.authorKızılırmak, Filiz
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:37Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:37Z
dc.date.issued2016en_US
dc.identifier.citationYüksel, İ. Ö., Köklü, E., Arslan, Ş., Çağırcı, G., Göksü Özaydın, E., Koç, P. ... Kızılırmak, F. (2016). Association of neutrophil/lymphocyte ratio with plaque morphology in patients with asymptomatic intermediate carotid artery stenosis. Korean Circulation Journal, 46(5), 699-705. https://dx.doi.org/10.4070/kcj.2016.46.5.699en_US
dc.identifier.issn1738-5520
dc.identifier.issn1738-5555
dc.identifier.urihttps://dx.doi.org/10.4070/kcj.2016.46.5.699
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3366
dc.descriptionWOS: 000384706100016en_US
dc.descriptionPubMed ID: 27721862en_US
dc.description.abstractBackground and Objectives: Non-calcified carotid plaques are more unstable than calcified plaques; and they are associated with a higher risk of rupture, thromboembolism, and consequently, stroke. The purpose of the present study is to compare calcified and non-calcified plaques that cause intermediate carotid artery stenosis with respect to neutrophil/lymphocyte ratio (NLR). Subjects and Methods: A total number of 139 asymptomatic patients with 50-70% stenosis of the carotid artery were included in this study. Carotid Doppler ultrasound imaging and computed tomography angiography were performed to divide the carotid artery plaques into two groups as calcified and non-calcified. Patients included in the calcified (n=73)and non-calcified (n=66) plaque groups were compared with respect to total neutrophil count, lymphocyte count and NLR. Results: Total lymphocyte count was statistically significantly lower in the non-calcified plaque group compared to the calcified plaque group (total lymphocyte count in non-calcified/calcified plaque groups [10(3)/mm(3)]: 2.1/2.3, respectively) (p=0.002). NLR was statistically significantly higher in the non-calcified plaque group compared to the calcified plaque group (NLR in non-calcified/calcified plaque groups: 2.6/2.1, respectively) (p<0.001). The cut-off value for NLR was found to be >2.54. Multivariate regression analysis showed that NLR was independently associated with non-calcified carotid artery plaques (odds ratio 5.686, 95% CI 2.498-12.944, p<0.001). Conclusions: NLR is increased in the presence of non-calcified carotid artery plaques that cause asymptomatic intermediate stenosis. Increased NLR can be used as a marker to assess the risk of rupture of non-calcified carotid artery plaques.en_US
dc.language.isoengen_US
dc.publisherKorean Soc Cardiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 Unported*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/*
dc.subjectAtherosclerosisen_US
dc.subjectCarotid Artery Stenosisen_US
dc.subjectNeutrophil Lymphocyte Ratioen_US
dc.subjectAtherosclerotic Plaqueen_US
dc.subjectStrokeen_US
dc.titleAssociation of neutrophil/lymphocyte ratio with plaque morphology in patients with asymptomatic intermediate carotid artery stenosisen_US
dc.typearticleen_US
dc.relation.ispartofKorean Circulation Journalen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0003-1919-3183en_US
dc.identifier.volume46en_US
dc.identifier.issue5en_US
dc.identifier.startpage699en_US
dc.identifier.endpage705en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.4070/kcj.2016.46.5.699en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ2en_US


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