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dc.contributor.authorCeylan, Hasan Hüseyin
dc.contributor.authorBilsel, Kerem
dc.contributor.authorBüyükpınarbaşılı, Nur
dc.contributor.authorCeylan, Hamid
dc.contributor.authorErdil, Mehmet
dc.contributor.authorTuncay, İbrahim
dc.contributor.authorŞen, Cengiz
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:36Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:36Z
dc.date.issued2016en_US
dc.identifier.citationCeylan, H. H., Bilsel, K., Büyükpınarbaşılı, N., Ceylan, H., Erdil, M., Tuncay, İ. ... Şen, C. (2016). Can chondral healing be improved following microfracture? The effect of adipocyte tissue derived stem cell therapy. Knee, 23(3), 442-449. https://dx.doi.org/10.1016/j.knee.2015.11.008en_US
dc.identifier.issn0968-0160
dc.identifier.issn1873-5800
dc.identifier.urihttps://dx.doi.org/10.1016/j.knee.2015.11.008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3362
dc.descriptionWOS: 000378963600017en_US
dc.descriptionPubMed ID: 27068292en_US
dc.description.abstractBackground: We aimed to investigate the effect of adipose tissue-derived mesenchymal stem cells (ADSCs) on chondral healing using the microfracture (MF) technique. Methods: Thirty male rabbits were randomly divided into three groups. Standard cylindrical osteochondral defects (OCDs) were created in the weight-bearing areas of the medial condyles of all the right knees; the defects were four millimeters in diameter and two millimeters in depth. The control group (group A) was restricted to spontaneous healing. For group B, we performed MF with a 1.5-mm drill. For group C, we applied MF using the same method and then applied 3 x 10(6) ADSCs to the defect area. At eight weeks post-operation, the subjects were sacrificed, and the distal femoral joint surfaces were evaluated histopathologically for chondral healing. The samples were scored according to the International Cartilage Repair Society (ICRS) scale. Results: The results for group C were significantly better than those for group A in terms of the surface properties (p = 0.003). The matrix evaluation was better for group A than for group C (p = 0.01). The cell distribution, cell viability and subchondral bone parameters were similar between the groups (p = 0.198, p = 0.387 and p = 0.699). The cartilage mineralization parameter was better for group C than for group A (p = 0.001). The signs of healing were better for group C than for group B, but the differences were not significant (p = 0.185). Conclusions: Improvements with additional ADSC treatments were not statistically significant in cases in which ADSC treatment was compared with isolated MF treatment.en_US
dc.description.sponsorshipIstanbul Bezmialem Valdf University Scientific Research Projects Department [9.2012/11]en_US
dc.description.sponsorshipThis study was supported by the Istanbul Bezmialem Valdf University Scientific Research Projects Department. Grant number was 9.2012/11. We thank Omer Uysal for the statistical analysis; Fatma Eyuboglu for the cell culture procedure assistance; Safak Sayar, Oznur Inan and Onder Huseyin Bas for the animal laboratory assistance.en_US
dc.language.isoengen_US
dc.publisherElsevier Science Bven_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdipocyte Tissue Derived Stem Cellen_US
dc.subjectOsteochondral Defecten_US
dc.subjectMicrofractureen_US
dc.subjectChondral Healingen_US
dc.subjectCartilage Repairen_US
dc.titleCan chondral healing be improved following microfracture? The effect of adipocyte tissue derived stem cell therapyen_US
dc.typearticleen_US
dc.relation.journalKneeen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-6742-8464en_US
dc.identifier.volume23en_US
dc.identifier.issue3en_US
dc.identifier.startpage442en_US
dc.identifier.endpage449en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.knee.2015.11.008en_US


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