dc.contributor.author | Ceylan, Hasan Hüseyin | |
dc.contributor.author | Bilsel, Kerem | |
dc.contributor.author | Büyükpınarbaşılı, Nur | |
dc.contributor.author | Ceylan, Hamid | |
dc.contributor.author | Erdil, Mehmet | |
dc.contributor.author | Tuncay, İbrahim | |
dc.contributor.author | Şen, Cengiz | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:01:36Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:01:36Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Ceylan, H. H., Bilsel, K., Büyükpınarbaşılı, N., Ceylan, H., Erdil, M., Tuncay, İ. ... Şen, C. (2016). Can chondral healing be improved following microfracture? The effect of adipocyte tissue derived stem cell therapy. Knee, 23(3), 442-449. https://dx.doi.org/10.1016/j.knee.2015.11.008 | en_US |
dc.identifier.issn | 0968-0160 | |
dc.identifier.issn | 1873-5800 | |
dc.identifier.uri | https://dx.doi.org/10.1016/j.knee.2015.11.008 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3362 | |
dc.description | WOS: 000378963600017 | en_US |
dc.description | PubMed ID: 27068292 | en_US |
dc.description.abstract | Background: We aimed to investigate the effect of adipose tissue-derived mesenchymal stem cells (ADSCs) on chondral healing using the microfracture (MF) technique. Methods: Thirty male rabbits were randomly divided into three groups. Standard cylindrical osteochondral defects (OCDs) were created in the weight-bearing areas of the medial condyles of all the right knees; the defects were four millimeters in diameter and two millimeters in depth. The control group (group A) was restricted to spontaneous healing. For group B, we performed MF with a 1.5-mm drill. For group C, we applied MF using the same method and then applied 3 x 10(6) ADSCs to the defect area. At eight weeks post-operation, the subjects were sacrificed, and the distal femoral joint surfaces were evaluated histopathologically for chondral healing. The samples were scored according to the International Cartilage Repair Society (ICRS) scale. Results: The results for group C were significantly better than those for group A in terms of the surface properties (p = 0.003). The matrix evaluation was better for group A than for group C (p = 0.01). The cell distribution, cell viability and subchondral bone parameters were similar between the groups (p = 0.198, p = 0.387 and p = 0.699). The cartilage mineralization parameter was better for group C than for group A (p = 0.001). The signs of healing were better for group C than for group B, but the differences were not significant (p = 0.185). Conclusions: Improvements with additional ADSC treatments were not statistically significant in cases in which ADSC treatment was compared with isolated MF treatment. | en_US |
dc.description.sponsorship | Istanbul Bezmialem Valdf University Scientific Research Projects Department [9.2012/11] | en_US |
dc.description.sponsorship | This study was supported by the Istanbul Bezmialem Valdf University Scientific Research Projects Department. Grant number was 9.2012/11. We thank Omer Uysal for the statistical analysis; Fatma Eyuboglu for the cell culture procedure assistance; Safak Sayar, Oznur Inan and Onder Huseyin Bas for the animal laboratory assistance. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Science Bv | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Adipocyte Tissue Derived Stem Cell | en_US |
dc.subject | Osteochondral Defect | en_US |
dc.subject | Microfracture | en_US |
dc.subject | Chondral Healing | en_US |
dc.subject | Cartilage Repair | en_US |
dc.title | Can chondral healing be improved following microfracture? The effect of adipocyte tissue derived stem cell therapy | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Knee | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-6742-8464 | en_US |
dc.identifier.volume | 23 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 442 | en_US |
dc.identifier.endpage | 449 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.knee.2015.11.008 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q1 | en_US |