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dc.contributor.authorGüler, Ekrem
dc.contributor.authorGeçmen, Çetin
dc.contributor.authorGüler Babür, Gamze
dc.contributor.authorKaraca, Oğuz
dc.contributor.authorHicaz Zencirkiran, Agus
dc.contributor.authorGüneş, Hacı Murat
dc.contributor.authorBatgerel, Ulankhuu
dc.contributor.authorElveran, Ali
dc.contributor.authorEsen, Ali Metin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:35Z
dc.date.issued2013en_US
dc.identifier.citationGüler, E., Geçmen, Ç., Güler Babür, G., Karaca, O., Hicaz Zencirkiran, A., Güneş, Hacı M. ... Esen, A. M. (2013). Adding lipoprotein(a) levels to the GRACE score to predict prognosis in patients with non-ST elevation acute coronary syndrome. Kardiologia Polska, 71(7), 695-701. https://dx.doi.org/10.5603/KP.2013.0156en_US
dc.identifier.issn0022-9032
dc.identifier.urihttps://dx.doi.org/10.5603/KP.2013.0156
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3356
dc.descriptionWOS: 000322659700006en_US
dc.descriptionPubMed ID: 23907902en_US
dc.description.abstractBackground: High levels of lipoprotein(a) [Lp(a)] are known to be a cardiovascular risk factor associated with premature coronary artery disease. In predicting the long term prognosis in acute coronary syndromes (ACS), the relationship between Lp(a) and risk scoring systems remains unclear. Aim: We investigated whether adding Lp(a) to the GRACE scoring system has an incremental value in predicting prognosis in ACS. Methods: 115 patients (mean age 64 +/- 11 years) with non-ST elevation acute coronary syndromes (NSTE-ACS) were enrolled in this prospective study. Patients were categorised into quartiles according to the Lp(a) levels. Statistically significant variables in the univariate analysis (haemoglobin, creatinine, age, left ventricular ejection fraction, previous myocardial infarction (MI) history, Killip class) were included in the multivariate analysis to determine the independent predictors of cardiovascular outcomes (mortality, rehospitalisation) with and without Lp(a) quartiles for one year follow-up. Results: Previous MI history and Lp(a) quartile were detected as independent predictors of combined cardiovascular events (OR: 2.969 [95% CI 1.413-6.240] and OR: 6.279 [95% CI 1.363-28.927] respectively). Lp(a) quartile also remained as an independent predictor for prognosis when added to a model based on GRACE risk score (OR: 2.589 [95% CI 1.402-4.780]). Serum Lp(a) levels were moderately correlated with GRACE risk score (r = 0.371; p < 0.001). Conclusions: Lipoprotein(a) has an additional prognostic value over GRACE risk score in predicting one-year adverse outcomes in NSTE-ACS. The combination of serum Lp(a) with GRACE risk score could provide enhanced risk stratification in patients with ACS.en_US
dc.language.isoengen_US
dc.publisherVia Medicaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLipoprotein(a)en_US
dc.subjectAcute Coronary Syndromesen_US
dc.subjectGrace Risk Scoreen_US
dc.titleAdding lipoprotein(a) levels to the GRACE score to predict prognosis in patients with non-ST elevation acute coronary syndromeen_US
dc.typearticleen_US
dc.relation.ispartofKardiologia Polskaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-4607-5724en_US
dc.authorid0000-0002-4281-0867en_US
dc.identifier.volume71en_US
dc.identifier.issue7en_US
dc.identifier.startpage695en_US
dc.identifier.endpage701en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5603/KP.2013.0156en_US
dc.identifier.wosqualityQ2en_US
dc.identifier.scopusqualityQ3en_US


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